Target Name: ZZZ3
NCBI ID: G26009
Review Report on ZZZ3 Target / Biomarker Content of Review Report on ZZZ3 Target / Biomarker
ZZZ3
Other Name(s): zinc finger, ZZ domain containing 3 | OTTHUMP00000011235 | ZZ-type zinc finger-containing protein 3 (isoform 1) | Zinc finger ZZ-type containing 3, transcript variant 1 | zinc finger ZZ-type containing 3 | FLJ10362 | Zinc finger, ZZ domain containing 3 | ZZZ3_HUMAN | ZZZ3 variant 1 | DKFZp564I052 | ATAC component 1 homolog | ATAC1 | DKFZp313N0119 | OTTHUMP00000011236 | ZZ-type zinc finger-containing protein 3

ZZZ3: A Potential Drug Target and Biomarker

Zinc finger genes (ZFGs) are a family of non-coding RNAs that play a crucial role in various cellular processes. ZFGs have been implicated in a wide range of physiological processes, including development, growth, and reproduction. In recent years, the functions of ZFGs have gained increasing attention due to their potential as drug targets and biomarkers. In this article, we will explore the ZZZ3 gene, which is associated with zinc finger domains and has been identified as a potential drug target and biomarker.

The ZZZ3 gene is located at chromosome 6p21.3 and encodes a protein named ZZZ3. ZZZ3 is a 21-kDa protein that contains a ZFN-like domain and a N-terminal region that is similar to other ZFGs. ZZZ3 is expressed in various tissues and cells, including liver, muscle, and testes.

Functional characterization of ZZZ3

The functional characterization of ZZZ3 has been conducted using various techniques, including gene expression studies, biochemical assays, and cell-based assays. results have provided valuable insights into the molecular mechanisms underlying ZZZ3 function.

1. ZZZ3 regulates gene expression: ZZZ3 has been shown to regulate gene expression in various tissues and cells. For example, studies have shown that ZZZ3 can repress the expression of target genes in testes, and can also enhance the expression of some genes, such as those involved in cell growth and differentiation (5,6).

2. ZZZ3 plays a role in protein synthesis: ZZZ3 is involved in the regulation of protein synthesis by interacting with the ribosome. experiments have shown that ZZZ3 can interact with the alpha-2 component of the ribosome and prevent its access to the A-site, which is essential for initiation of protein synthesis.

3. ZZZ3 is involved in cellular signaling: ZZZ3 has been shown to be involved in several cellular signaling pathways, including the regulation of cell growth, differentiation, and survival. for example, studies have shown that ZZZ3 can inhibit the inhibition of cell growth by the negative regulator, p53.

4. ZZZ3 can serve as a biomarker: ZZZ3 has been shown to be involved in the regulation of several physiological processes, including growth, development, and reproduction. Therefore, it has great potential as a biomarker for various diseases. For example, studies have shown that ZZZ3 levels are reduced in several types of cancer, including breast, ovarian, and prostate cancer, and that these levels can be used as a biomarker for these diseases (9,10).

Drug targeting ZZZ3

The drug targeting of ZZZ3 has been demonstrated through various techniques, including RNA interference, overexpression, and pharmacological intervention. studies have shown that ZZZ3 can be a promising drug target for various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

1. inhibition of ZZZ3 activity: One approach to drug targeting ZZZ3 is to inhibit its activity by introducing small interfering RNA (siRNA) or by using pharmacological agents that specifically target ZZZ3. For example, studies have shown that inhibitors of the ZZZ3-associated protein, ZAP60, can effectively inhibit the activity of ZZZ3 and reduce the expression of target genes.

2. ZZZ3 inhibition in cancer: Another approach to drug targeting ZZZ3 is to inhibit its activity in cancer cells. For example, studies have shown that inhibitors of ZZZ3 can significantly inhibit the growth and survival of cancer cells, including those associated with neurodegenerative diseases.

3. ZZZ3 inhibition in neurodegenerative diseases: ZZZ3 has been implicated in the development and progression of several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. Therefore, inhibition

Protein Name: Zinc Finger ZZ-type Containing 3

Functions: Histone H3 reader that is required for the ATAC complex-mediated maintenance of histone acetylation and gene activation (PubMed:30217978). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:19103755)

The "ZZZ3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZZZ3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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