AARS2 Related Diseases

AARS2

Related Diseases

1) Neurodevelopmental Disorders
Cerebellar Atrophy, Developmental Delay, and Seizures, also known as neurodevelopmental disorders, is related to chd2-related neurodevelopmental disorders and attention deficit-hyperactivity disorder. An important gene associated with Cerebellar Atrophy, Developmental Delay, and Seizures is KCNMA1 (Potassium Calcium-Activated Channel Subfamily M Alpha 1). The drugs Methylphenidate and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include brain, prefrontal cortex and heart, and related phenotypes are eeg abnormality and global developmental delay

2) Cardiomyopathy, Hypertrophic
Hypertrophic Cardiomyopathy, also known as hypertrophic obstructive cardiomyopathy, is related to cardiomyopathy, familial hypertrophic, 1 and cardiomyopathy, familial hypertrophic, 4. An important gene associated with Hypertrophic Cardiomyopathy is MYH7 (Myosin Heavy Chain 7), and among its related pathways/superpathways are Cardiac conduction and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. The drugs Spironolactone and Ranolazine have been mentioned in the context of this disorder. Affiliated tissues include heart, skeletal muscle and brain, and related phenotypes are muscle and normal

3) Leukodystrophies
Leukodystrophy, also known as leukodystrophies, is related to metachromatic leukodystrophy and krabbe disease, and has symptoms including back pain, headache and pain. An important gene associated with Leukodystrophy is EIF2B5 (Eukaryotic Translation Initiation Factor 2B Subunit Epsilon), and among its related pathways/superpathways are Neural Stem Cells and Lineage-specific Markers and Translation factors. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone marrow and brain, and related phenotypes are no effect and no effect

4) Optic Neuropathy
Optic Nerve Disease, also known as optic neuropathy, is related to leber optic atrophy and dystonia and toxic optic neuropathy, and has symptoms including eye manifestations and sciatica. An important gene associated with Optic Nerve Disease is TYR (Tyrosinase), and among its related pathways/superpathways are Metabolism and "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.". The drugs Dalfampridine and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include optic nerve, eye and retina, and related phenotype is vision/eye.

5) Frontotemporal Dementia With Amyotrophic Lateral Sclerosis
Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis 1, also known as amyotrophic lateral sclerosis and/or frontotemporal dementia, is related to frontotemporal dementia and/or amyotrophic lateral sclerosis 2 and frontotemporal dementia and/or amyotrophic lateral sclerosis 4, and has symptoms including muscle weakness, paraparesis and abnormality of extrapyramidal motor function. An important gene associated with Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis 1 is C9orf72 (C9orf72-SMCR8 Complex Subunit), and among its related pathways/superpathways is Neuroscience. The drugs Memantine and Excitatory Amino Acid Antagonists have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, spinal cord and brain, and related phenotypes are abnormal upper motor neuron morphology and frontotemporal dementia

The "AARS2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about AARS2 comprehensively including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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