ABCC1: A Potential Drug Target and Biomarker for CFTR and MRP Subunits

Target Name: ABCC1

NCBI ID: G4363

ABCC1

ABCC1: A Potential Drug Target and Biomarker for CFTR and MRP Subunits

The CFTR (Channel CFTR) and MRP (Channel MRP) proteins play crucial roles in the regulation of intracellular signaling pathways, including DNA replication, gene expression, and cell signaling. They are also involved in the transport of various molecules across cell membranes. The abnormalities in CFTR and MRP gene function have been implicated in numerous diseases, including cystic fibrosis, heart failure, and cancer. Therefore, the study of ABCC1, a member of the ATP-binding cassette (ABC) subfamily C, has significant implications for the development of new therapeutic approaches.

ABCC1: Structure, Functions, and Interactions

The ABCC1 protein is a 21-kDa integral membrane protein that consists of an N-terminal transmembrane domain, a cytoplasmic domain, and an C-terminal protein domain. It has a unique topology, with the cytoplasmic domain reaching the outer membrane of the cell and the N-terminal transmembrane domain reaching into the cytoplasm. The cytoplasmic domain contains a putative ATP-binding site, which is involved in the regulation of cellular processes, such as cell signaling, DNA replication, and gene expression.

Functional characterization of ABCC1 has shown that it is involved in various cellular processes, including intracellular signaling, DNA replication, and transport. For example, ABCC1 has been shown to be involved in the regulation of DNA replication, with the cytoplasmic domain interacting with the replication complex to prevent the formation of a replication bubble and to maintain the integrity of the replication complex. Additionally, the cytoplasmic domain has been shown to be involved in the regulation of cell signaling, with the putative ATP-binding site contributing to the regulation of protein kinase signaling.

Despite its involvement in various cellular processes, the functional significance of ABCC1 is not well understood. Therefore, the study of its potential drug targets and biomarkers is of great interest.

Potential Drug Targets and Biomarkers

Several studies have suggested that ABCC1 may serve as a potential drug target for various diseases. First, the abnormalities in ABCC1 function have been implicated in the development and progression of cystic fibrosis, a genetic disease that is characterized by chronic lung infections and progressive lung damage. ABCC1 has been shown to be involved in the regulation of the transport of chloride ions across the cell membrane, which is critical for the development and progression of cystic fibrosis. Therefore, targeting ABCC1 with drugs that modulate its function may be an effective strategy for the treatment of cystic fibrosis.

Second, the abnormalities in ABCC1 function have also been implicated in the development and progression of heart failure, a condition that is characterized by the inability of the heart to pump enough blood to meet the body's needs. ABCC1 has been shown to be involved in the regulation of the contractility of heart muscle cells, which is critical for the development and progression of heart failure. Therefore, targeting ABCC1 with drugs that modulate its function may be an effective strategy for the treatment of heart failure.

Third, the abnormalities in ABCC1 function have also been implicated in the development and progression of various cancers, including breast, ovarian, and prostate cancers. ABCC1 has been shown to be involved in the regulation of cell signaling, including the regulation of cell proliferation and apoptosis. Therefore, targeting ABCC1 with drugs that modulate its function may be an effective strategy for the treatment of cancers.

In addition to its potential as a drug target, ABCC1 has also been shown to be a potential biomarker for various diseases. For example, the abnormalities in ABCC1 function have been

Protein Name: ATP Binding Cassette Subfamily C Member 1

Functions: Mediates export of organic anions and drugs from the cytoplasm (PubMed:7961706, PubMed:16230346, PubMed:9281595, PubMed:10064732, PubMed:11114332). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:7961706, PubMed:16230346, PubMed:9281595, PubMed:10064732, PubMed:11114332). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595). Hydrolyzes ATP with low efficiency (PubMed:16230346). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity). Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export (PubMed:36070769). Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway (PubMed:36070769)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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