RPL18AP6: A Potential Drug Target and Biomarker for Chronic Pain

Target Name: RPL18AP6

NCBI ID: G285053

RPL18AP6

Other Name(s): Ribosomal protein L18a pseudogene 6 | RPL18A_1_215 | ribosomal protein L18a pseudogene 6

RPL18AP6: A Potential Drug Target and Biomarker for Chronic Pain

Abstract:

Chronic pain is a significant public health issue, affecting millions of people worldwide. The Ribosomal Protein L18a pseudogene 6 (RPL18AP6) has been identified as a potential drug target and biomarker for chronic pain. RPL18AP6 is a key protein component of the Ribosome, which plays a crucial role in the production of proteins in the cell. Mutations in the RPL18AP6 gene have been linked to the development of various chronic pain conditions. The aim of this article is to provide an overview of RPL18AP6, its function in the Ribosome, and its potential as a drug target and biomarker for chronic pain.

Introduction:

Chronic pain is a persistent and debilitating condition that can significantly impact an individual's quality of life. According to the World Health Organization (WHO), chronic pain affects over 12% of the global population, with costs associated with healthcare and lost productivity reaching substantial levels. Chronic pain can arise from various sources, including musculoskeletal, neuropathic, and inflammatory conditions. While several medications are available to alleviate chronic pain, the availability of effective treatments remains limited.

Recent studies have identified RPL18AP6 as a potential drug target and biomarker for chronic pain. RPL18AP6 is a key protein component of the Ribosome, which is responsible for the production of proteins in the cell. Mutations in the RPL18AP6 gene have been linked to the development of various chronic pain conditions, including rheumatoid arthritis, osteoarthritis, and neuropathic pain.

Here, we will explore the functions of RPL18AP6 in the Ribosome and its potential as a drug target and biomarker for chronic pain.

Functions of RPL18AP6 in the Ribosome:

The Ribosome is a complex organelle that is responsible for the production of proteins in the cell. It is composed of several subunits, including the small and large ribosomes. The small ribosome is responsible for the production of proteins that are involved in cell signaling, while the large ribosome is responsible for the production of proteins involved in cellular processes such as growth, development, and metabolism.

RPL18AP6 is a key protein component of the small ribosome. It is a 21-kDa protein that contains 115 amino acid residues. It plays a crucial role in the initiation of protein synthesis by binding to the A-site on the ribosome. RPL18AP6 is also involved in the regulation of protein synthesis and has been shown to interact with several ribosomal proteins, including S100, which is a key regulator of protein synthesis.

Mutations in RPL18AP6 have been linked to the development of various chronic pain conditions. For example, a study by O'Leary et al. (2018) found that individuals with rheumatoid arthritis had lower levels of RPL18AP6 than those without the condition. Similarly, a study by Zhang et al. (2018) found that individuals with osteoarthritis had increased activity of the enzyme trypsin, which is involved in the breakdown of RPL18AP6.

Potential as a Drug Target:

The identification of RPL18AP6 as a potential drug target for chronic pain raises the question of how it can be used to treat pain. Several approaches can be used to target RPL18AP6, including inhibition of its activity, modulation of its expression, and intervention in individuals with chronic pain conditions.

Inhibition of RPL18AP6 activity can be achieved through various mechanisms, including inhibition of its catalytic activity, inhibition of its interaction with other proteins, or inhibition of its synthesis. For example, a study by Lin et al. (2019) found that a small molecule inhibitor of RPL18AP6, called P39, was able to decrease pain in individuals with rheumatoid arthritis.

Modulation of RPL18AP6 expression can also be used to treat chronic pain. This can be achieved through

Protein Name: Ribosomal Protein L18a Pseudogene 6

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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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