Inhibition of 7SLN-Protein Stability: Potential Therapeutic Applications

Target Name: RN7SL2

NCBI ID: G378706

RN7SL2

Other Name(s): 7SL1c | 7L30.1 | RNA component of signal recognition particle 7SL2 | RNSRP2 | 7L1C

Inhibition of 7SLN-Protein Stability: Potential Therapeutic Applications

The RNA-protein interactions are a critical aspect of gene regulation, and the post-translational modification (PTM) of RNA is a key mechanism involved in this regulation. One of the most well-known PTMs of RNA is the 7-nucleotide stem- loop (7SLN), also known as the 7-base stem-loop. The 7SLN is a common PTM that is found in various RNA molecules, including mRNAs, snRNAs, and microRNAs. One of the unique features of the 7SLN is its role in regulating gene expression and has been implicated in various diseases.

One of the well-known drugs that targets the 7SLN is RN7SL2 (7SL1c). RN7SL2 is a small molecule inhibitor of the 7SLN-protein stability, which can specifically target the 7SLN in mRNAs and snRNAs. By inhibiting the stability of the 7SLN, RN7SL2 can prevent the translation of these RNA molecules, leading to reduced gene expression and potentially contribute to the development of various diseases.

In this article, we will provide a comprehensive overview of RN7SL2, including its structure, mechanism of action, and potential therapeutic applications.

Structure and Mechanism of Action

The 7SLN is a palindromic RNA molecule composed of 7 nucleotide units, paired in pairs. Under normal circumstances, 7SLN interacts with neighboring nucleic acid units through hydrogen bonds to form a stable structure. However, when 7SLN is phosphorylated, its stability is reduced because phosphorylation breaks hydrogen bonds. Therefore, RNA molecules often undergo unwinding after phosphorylation, resulting in reduced stability, making them susceptible to external factors, including some disease molecules.

RN7SL2 is a small molecule compound that inhibits 7SLN phosphorylation. Its structure is similar to 7SLN, but with some modifications. It contains an acetamide group at the N-terminus and an amine group at the C-terminus. These modifications can affect the properties of the RNA molecule, including its stability within the cell.

The mechanism of action of RN7SL2 is to inhibit its phosphorylation by interacting with the N-terminus of 7SLN. By inhibiting the phosphorylation of 7SLN, RN7SL2 can reduce the stability of 7SLN, thereby inhibiting its translation of mRNA and snRNA. This prevents the RNA molecule from being translated correctly into protein, thereby inhibiting its biological function.

Potential Therapeutic Applications

RN7SL2 has broad application prospects in drug screening and disease treatment. Since RNA is an important target of disease molecules, RNA inhibition technology is widely used in drug development. RNA inhibition technologies include RNA interference, RNA-binding protein inhibition, and RNA-binding small molecule inhibition. Unlike RNA interference and RNA-binding protein inhibition, RNA-binding small molecule inhibition can inhibit the interaction between RNA molecules and small molecules, and therefore has a wider inhibition range and higher specificity.

RN7SL2 is a potent RNA-binding small molecule inhibitor that inhibits the interaction between 7SLN and small molecules, thereby inhibiting the phosphorylation of 7SLN. This provides new ideas and experimental methods for the study of RNA-binding small molecule inhibition.

Conclusion

RNA-protein interactions are critical for gene regulation, and the post-translational modification (PTM) of RNA is a key mechanism involved in this regulation. The 7-nucleotide stem-loop (7SLN) is a well-known PTM of RNA that has been implicated in various diseases. One of the unique features of the 7SLN is its role in regulating gene expression, and RN7SL2 is a small molecule inhibitor of the 7SLN-protein stability, which can specifically target the 7SLN in mRNAs and snRNAs. By inhibiting the Stability of the 7SLN, RN7SL2 can prevent the translation of these RNA molecules, leading to reduced gene expression and potentially contribute to the development of various diseases.

Protein Name: RNA Component Of Signal Recognition Particle 7SL2

The "RN7SL2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RN7SL2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets