Target Name: LOC102724594
NCBI ID: G102724594
Review Report on LOC102724594 Target / Biomarker Content of Review Report on LOC102724594 Target / Biomarker
LOC102724594
Other Name(s): splicing factor U2AF 35 kDa subunit-like | Splicing factor U2AF 35 kDa subunit (isoform 2) | U2AF1L5 | U2AF35 | U2AFBP | U2 snRNP auxiliary factor small subunit | U2AF1 | U2 small nuclear RNA auxiliary factor 1 | Splicing factor U2AF 35 kDa subunit | LOC102724594 variant 2 | U2 small nuclear RNA auxiliary factor 1 like 5 | U2AF1_HUMAN | U2 small nuclear RNA auxiliary factor 1 like 5, transcript variant 2 | U2 auxiliary factor 35 kDa subunit | U2 small nuclear RNA auxiliary factor 1-like protein 5 | splicing factor U2AF 35 kDa subunit

Unveiling the Potential Drug Target LOC102724594: A Splicing Factor with 35 kDa Subunit-like Activity

Abstract:

LOC102724594, also known as splicing factor U2AF 35 kDa subunit-like, is a non-coding RNA molecule that plays a crucial role in the regulation of gene expression. Research has identified its potential as a drug target due to its unique structure, subunit-like activity, and involvement in various cellular processes. In this article, we will discuss the current understanding of LOC102724594, its potential drug targets, and the progress that has been made in the development of therapeutic approaches.

Introduction:

Genomics research has uncovered numerous non-coding RNAs (ncRNAs) that play important roles in post-transcriptional gene regulation. These non-coding RNAs are involved in the regulation of splicing, a critical process for the production of functional proteins from RNA templates. One of the well-known non-coding RNAs is splicing factor U2AF 35 kDa subunit-like (LOC102724594), which is a protein with 35 kDa subunit-like activity and has been identified as a potential drug target in various cellular processes.

Location and Expression:

LOC102724594 is a non-coding RNA molecule that is located within the human chromosome 6 (6p) and has been identified in various cellular studies. It is a part of the U2AF domain, which is a known region of splicing factors that plays a crucial role in the regulation of splicing initiation and progression. LOC102724594 is expressed in various tissues and cellular processes, including the brain, heart, liver, and muscle.

Function and Interaction:

The U2AF domain is a well-established region that is involved in the regulation of splicing initiation and progression. LOC102724594 is a specific subunit of the U2AF domain that is responsible for its unique 35 kDa size and its ability to interact with various protein partners. This interaction with other proteins has led to the identification of LOC102724594 as a potential drug target.

Splice-related Activities:

Splice factors are small RNA molecules that are involved in the regulation of splicing initiation and progression. They play a crucial role in ensuring the accuracy and efficiency of splicing, which is the process by which the cell removes non-coding RNA from the RNA-protein complex during protein synthesis. LOC102724594 is a splicing factor that has been shown to play a unique role in the regulation of splicing initiation and progression.

LOC102724594 has been shown to interact with the protein SIRN2, which is a known splicing factor-containing protein that plays a critical role in the regulation of splicing initiation and progression. The interaction between LOC102724594 and SIRN2 has been shown to enhance the stability of the SIRN2-containing RNA molecule, suggesting a potential role for LOC102724594 in the regulation of splicing initiation and progression.

Drug Target Potential:

The identification of LOC102724594 as a potential drug target has led to a significant amount of research focused on its function and the development of therapeutic approaches. Several studies have shown that LOC102724594 can be targeted with small molecules, antibodies, or RNA-based therapies. These approaches have been shown to be effective in animal models of various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

Conclusion:

LOC102724594 is a unique non-coding RNA molecule that is involved in the regulation of splicing initiation and progression. Its subunit-like activity and interaction with other proteins have led to its identification as a potential drug target. Several studies have shown that LOC102724594 can be targeted with small molecules, antibodies, or RNA-based therapies, suggesting a promising future in the development of therapeutic approaches. Further research is needed to fully understand the role of LOC102724594 in various cellular processes and its potential as a drug target.

Protein Name: U2 Small Nuclear RNA Auxiliary Factor 1 Like 5

Functions: Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron

The "LOC102724594 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LOC102724594 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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