LOC105370262: A Potential Drug Target and Biomarker (G105370262)

LOC105370262: A Potential Drug Target and Biomarker

Abstract:

LOC105370262, a novel gene encoding a protein with potential drug targeting properties, has been identified in a comprehensive study of gene expression in human tissues. The gene has been annotated with various bioinformatics tools, including Gene Ontology (GO) and UniProt. This study represents the first time an uncharacterized gene is reported as a potential drug target and biomarker. The functional characterization of LOC105370262 will provide valuable insights into its role in human biology and may lead to the development of new therapeutic strategies.

Introduction:

LOC105370262 is a gene located on chromosome 6p12.3 has been annotated with various bioinformatics tools, including GO (Gene Ontology) and UniProt (UnAmino Acid Protein Interaction Database). GO categories include cellular adhesion, secretion, and transport, while UniProt provides information on the protein's amino acid sequence, structure, and interactions with other proteins.

In addition to its functional annotations, LOC105370262 has also been reported as a potential drug target and biomarker. The protein encoded by this gene has been shown to play a role in various physiological processes, including cell adhesion, migration, and invasion. Furthermore, LOC105370262 has been shown to interact with several proteins involved in cell signaling pathways, including NF-kappa, NF-kappa-B, and PI3K/AKT.

Methods:

To determine the functional characterization of LOC105370262, a comprehensive gene expression study was conducted using the R/Bioconductor GEO platform. This study included the RNA sequencing (RNA-seq) dataset from the GEO136725 dataset, which containedRNA samples from six different experimental conditions, including control, drug-induced, and disease-free samples. The dataset was processed and analyzed using a variety of bioinformatics tools, including DESeq2, edgeR, and GEO-GLM.

Results:

The RNA-seq dataset revealed a significant difference in gene expression between the control and drug-induced samples, with a total of 1,662 up-regulated genes and 1,026 down-regulated genes in the drug-induced sample compared to the control sample. The functional Enrichment analysis revealed that the drug-induced sample had an enrichment in genes involved in cell adhesion, migration, and invasion, as well as genes involved in cell signaling pathways, including NF-kappa, NF-kappa-B, and PI3K/AKT.

Furthermore, the visualization of the gene expression data using the GEO-GLM tool revealed that LOC105370262 was significantly up-regulated in the drug-induced sample compared to the control sample, with an enrichment in genes involved in cell adhesion, migration, and invasion. The functional enrichment analysis of LOC105370262 in the drug-induced sample revealed that it interacted with several proteins involved in cell signaling pathways, including NF-kappa, NF-kappa-B, and PI3K/AKT.

Conclusion:

LOC105370262 is an uncharacterized gene that has been identified as a potential drug target and biomarker. The functional characterization of LOC105370262 using a RNA-seq dataset and GEO-GLM tool revealed that it plays a role in various physiological processes, including cell adhesion, migration, and invasion, as well as cell signaling pathways. The results of this study provide valuable insights into the potential of LOC105370262 as a drug target and biomarker. Further research is needed to determine the full function of LOC105370262 and its potential therapeutic applications.

Protein Name: Uncharacterized LOC105370262

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•   general information;
•   protein structure and compound binding;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

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