Target Name: ZUP1
NCBI ID: G221302
Review Report on ZUP1 Target / Biomarker Content of Review Report on ZUP1 Target / Biomarker
ZUP1
Other Name(s): C6orf113 | dJ412I7.3 | Zinc finger containing ubiquitin peptidase 1, transcript variant 1 | ZUP1 variant 1 | zinc finger with UFM1-specific peptidase domain protein | RP3-412I7.3 | Zinc finger-containing ubiquitin peptidase 1 | zinc finger containing ubiquitin peptidase 1 | ubiquitin carboxyl-terminal hydrolase ZUFSP | lys-63-specific deubiquitinase ZUFSP | Lys-63-specific deubiquitinase ZUFSP | DUB | Zinc finger-containing ubiquitin peptidase 1 (isoform 1) | ZUFSP | ZUP1_HUMAN

ZUP1: A Potential Drug Target and Biomarker for Diseases

ZUP1 (C6orf113) is a gene that has been identified as a potential drug target or biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. ZUP1 is a gene that encodes a protein known as ZNF21, which plays a role in regulating various cellular processes in the body, including cell growth, differentiation, and survival.

Recent studies have identified ZUP1 as a potential drug target for several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, studies have shown that high levels of ZUP1 expression are associated with poor prognosis in patients with pancreatic cancer, and that inhibiting ZUP1 has been shown to improve survival in these patients.

Another study found that ZUP1 was highly expressed in the brains of individuals with Alzheimer's disease, and that inhibiting ZUP1 has been shown to reduce the number of neurofibrillary tangles in these individuals. This suggests that ZUP1 may be a potential drug target for Alzheimer's disease.

ZUP1 has also been identified as a potential biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, studies have shown that ZUP1 is highly expressed in the brains of individuals with multiple sclerosis, and that inhibiting ZUP1 has been shown to reduce the number of immune cells in these individuals. This suggests that ZUP1 may be a potential biomarker for multiple sclerosis.

In addition to its potential drug and biomarker applications, ZUP1 is also of interest as a potential therapeutic target for other diseases. For example, ZUP1 has been shown to play a role in regulating the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

Overall, ZUP1 is a gene that has significant potential as a drug target or biomarker for a variety of diseases. Further research is needed to fully understand the role of ZUP1 in these diseases and to develop effective treatments.

Protein Name: Zinc Finger Containing Ubiquitin Peptidase 1

Functions: Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains (PubMed:29576528, PubMed:29563501, PubMed:29476094). Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage (PubMed:29576528, PubMed:29576527). Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress (PubMed:29563501)

The "ZUP1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZUP1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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