MIR3118-3: A Potential Drug Target and Biomarker (G100422844)
MIR3118-3: A Potential Drug Target and Biomarker
Molecular Targets in Cancer
MIR3118-3, a protein encoded by the gene IR3118-3, has been identified as a potential drug target and biomarker in cancer. It is a member of the insulin-like growth factor receptor (IGFR) family, which is a receptor that plays a crucial role in cell growth, survival, and angiogenesis. MIR3118-3 has been shown to be overexpressed in various types of cancer, including breast, ovarian, and colorectal cancer.
The Potential Drug Target
MIR3118-3 is a potential drug target because it is involved in cell signaling pathways that are often disrupted in cancer. One of the most significant disruptions is the loss of the insulin-like growth factor receptor, which leads to an imbalance of signaling pathways that promote cancer growth. MIR3118-3 helps to maintain the sensitivity of cancer cells to insulin, which is a critical factor in their growth and survival.
The Breakdown of MIR3118-3 Signaling
MIR3118-3 is involved in several signaling pathways that promote cancer growth, including the TGF-β pathway, the PI3K/Akt pathway, and the NF-kappa-B pathway. These pathways are often disrupted in cancer, leading to an increase in cell proliferation and survival. MIR3118-3 helps to maintain the sensitivity of cancer cells to insulin, which is critical for the growth and survival of these cells.
MIR3118-3 as a Biomarker
MIR3118-3 has also been shown to be a potential biomarker for cancer. The expression of MIR3118-3 has been shown to be associated with poor prognosis in various types of cancer, including breast, ovarian, and colorectal cancer. Additionally, higher MIR3118-3 expression has been shown to be associated with a higher risk of recurrence in breast cancer.
MIR3118-3 as a Potential Drug
The potential drug target for MIR3118-3 is related to the inhibition of cancer cell signaling pathways that are often disrupted in cancer. One approach to inhibiting MIR3118-3 is to target the PI3K/Akt pathway, which is a critical signaling pathway in cancer.
Anti-MIR3118-3 Treatment
Several anti-MIR3118-3 drugs have been developed as potential treatments for cancer. For example, a small molecule inhibitor of the PI3K/Akt pathway, known as SM-30, has been shown to inhibit MIR3118-3 and reduce the growth of cancer cells. Additionally, an anti-MIR3118-3 monoclonal antibody, known as AMG 701, has been shown to inhibit the growth of cancer cells and decrease their survival.
Conclusion
MIR3118-3 is a protein that is involved in several signaling pathways that promote cancer growth. Its expression is often disrupted in cancer, and it has been shown to be associated with poor prognosis in various types of cancer. As a potential drug target and biomarker, MIR3118-3 is a promising target for cancer treatments. Further research is needed to fully understand the role of MIR3118-3 in cancer and to develop effective treatments.
Protein Name: MicroRNA 3118-3
The "MIR3118-3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MIR3118-3 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
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