CDHR4: A Potential Drug Target and Biomarker for Diseases (G389118)

Target Name: CDHR4

NCBI ID: G389118

CDHR4

CDHR4: A Potential Drug Target and Biomarker for Diseases

Cadherins are a family of transmembrane proteins that play a crucial role in cell-cell adhesion. CDHR4, a member of the cadherin family, has been identified as a potential drug target or biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. In this article, we will explore the biology of CDHR4 and its potential as a drug target.

Background

CDHR4 is a member of the cadherin family, which includes 21 different proteins that are involved in cell-cell adhesion. The cadherins are transmembrane proteins that consist of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain is involved in cell adhesion, while the transmembrane domain is responsible for the protein's stability and functions as a receptor. The intracellular domain is involved in the regulation of the protein's stability and interactions with other proteins.

CDHR4 is a 21-kDa protein that is expressed in various tissues, including brain, heart, and pancreas. It is involved in cell-cell adhesion and has been implicated in several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

CDHR4 functions as a negative regulator of the Wnt/FGF signaling pathway, which is a critical pathway for cell-cell adhesion and growth. The Wnt/FGF signaling pathway is a transmembrane signaling pathway that is involved in the regulation of cell proliferation, differentiation, and survival. The pathway is activated by the neurotransmitter Wnt, which is a protein that is produced by the wnt gene. The FGF receptor is a transmembrane protein that is involved in the regulation of cell proliferation and differentiation.

CDHR4 is a negative regulator of the Wnt/FGF signaling pathway because it interacts with the FGF receptor and prevents it from activating the pathway. This interaction between CDHR4 and the FGF receptor is critical for the regulation of cell proliferation and differentiation.

CDHR4 has been shown to be involved in several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, studies have shown that high levels of CDHR4 are associated with poor prognosis in patients with pancreatic cancer, and that inhibition of CDHR4 has been shown to be effective in treating neurodegenerative diseases.

Drug Targeting

CDHR4 is a potential drug target due to its involvement in several diseases. One of the main strategies for targeting CDHR4 is to inhibit its function as a negative regulator of the Wnt/FGF signaling pathway. This can be done by small molecules, such as inhibitors of the FGF receptor, or by monoclonal antibodies (MCAs), which are laboratory-produced antibodies that can bind to specific proteins.

Another strategy for targeting CDHR4 is to activate its function as a positive regulator of the Wnt/FGF signaling pathway. This can be done by small molecules that stimulate the production of Wnt, or by drugs that promote the interaction between CDHR4 and the FGF receptor.

CDHR4 has also been shown to be involved in several biomarkers that can be used for disease diagnosis and monitoring. For example, studies have shown that the expression of CDHR4 is associated with poor prognosis in patients with pancreatic cancer, and that inhibition of CDHR4 has been shown to be effective in treating neurodegenerative diseases.

Conclusion

CDHR4 is a protein that is involved in cell-cell adhesion and has been implicated in several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its function as a negative regulator of the Wnt/FGF signaling pathway makes it a potential drug target, and its potential as a biomarker makes it an attractive target for the development of new therapies. Further research is needed to fully understand the role of CDHR4 in disease and to develop effective treatments.

Protein Name: Cadherin Related Family Member 4

Functions: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity)

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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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