CEACAM5: A Potential Drug Target and Biomarker (G1048)

Target Name: CEACAM5

NCBI ID: G1048

CEACAM5

CEACAM5: A Potential Drug Target and Biomarker

The search for new treatments and therapies for various diseases has led to the discovery of promising biomarkers and drug targets. One such biomarker that has gained attention is CEACAM5, a protein that is expressed in the carcinoembryonic antigen (CEA) family. CEA is a glycoprotein that is expressed in a variety of tissues, including the brain, pancreas, and gastrointestinal tract. It is often used as a marker for cancer, as its levels tend to increase in the presence of cancer.

The CEA family has four isoforms, CEA-A, CEA-B, CEA-C, and CEA-D. Each isoform has a different molecular weight and function. CEA-A is the most abundant isoform and is expressed in various tissues, including the brain, pancreas, and gastrointestinal tract. CEA-B is expressed in the lungs and is associated with the development of lung cancer. CEA-C is expressed in the skin and is associated with skin cancer. CEA-D is the least abundant isoform and is expressed in the testes.

CEACAM5 is a member of the CEA family and is expressed in various tissues, including the brain, pancreas, and gastrointestinal tract. It is a glycoprotein with a molecular weight of approximately 180 kDa. CEACAM5 is involved in various physiological processes in the body, including cell signaling and inflammation.

One of the key functions of CEACAM5 is its role in cell signaling. CEACAM5 is a protein that is involved in the NF-kappa signaling pathway, a pathway that is involved in cell growth, differentiation, and survival. This pathway is a key factor in the development and progression of many diseases, including cancer.

In cancer, CEACAM5 is often expressed at higher levels than in non-cancerous tissues. This is because cancer cells have the ability to evade the normal cell signaling pathways that are responsible for regulating growth and differentiation. By bypassing these pathways, cancer cells are able to continue to grow and multiply uncontrollably.

CEACAM5 is also involved in inflammation. As an immune system protein, CEACAM5 is involved in the regulation of inflammation and immune responses. This is important because inflammation can contribute to the development and progression of many diseases, including cancer.

In addition to its role in cell signaling and inflammation, CEACAM5 is also involved in the development and progression of cancer. Studies have shown that CEACAM5 is often expressed at higher levels in tissues that are more likely to develop cancer, such as the lungs, pancreas, and gastrointestinal tract. This suggests that CEACAM5 may be a potential drug target for cancer.

Drugs that target CEACAM5 have the potential to treat a variety of diseases, including cancer. By inhibiting the activity of CEACAM5, drugs can reduce the growth and proliferation of cancer cells. This can lead to a reduction in the size and number of tumors, as well as improved overall health and quality of life for patients.

In conclusion, CEACAM5 is a protein that is expressed in various tissues and is involved in various physiological processes in the body. Its role in cell signaling and inflammation makes it a potential drug target for cancer. By inhibiting the activity of CEACAM5, drugs can treat a variety of diseases and improve the quality of life for patients. Further research is needed to fully understand the role of CEACAM5 in disease and to develop effective treatments.

Protein Name: CEA Cell Adhesion Molecule 5

Functions: Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050)

The "CEACAM5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CEACAM5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets