Unlocking the Potential of Ribosomal Protein S17 Pseudogene 16 as a Drug Target or Biomarker

Target Name: RPS17P16

NCBI ID: G402057

RPS17P16

Other Name(s): ribosomal protein S17 pseudogene 16 | RPS17_8_1748 | Ribosomal protein S17 pseudogene 16

Unlocking the Potential of Ribosomal Protein S17 Pseudogene 16 as a Drug Target or Biomarker

Introduction

Ribosomal protein S17 (RPS17) is a key protein that plays a crucial role in the regulation of gene expression and cell signaling. The protein is expressed in most eukaryotic cells and is highly conserved across different species. It is composed of a single polypeptide chain with a calculated molecular mass of 43 kDa. One of the unique features of RPS17 is its pseudogene, RPS17P16, which is aDNA copy of the RPS17 gene that is usually inactive. However, RPS17P16 can be transcribed and translated into a functional protein, encoded by the open reading frame (ORF) RPS17P16.

The RPS17 gene is located on chromosome 17q21 and is one of the most highly conserved genes in the human genome. It is involved in various cellular processes, including DNA replication, transcription, and translation. The protein encoded by RPS17 is a key regulator of gene expression, responsible for ensuring the accurate assembly and processing of RNA molecules.

The pseudogene, RPS17P16, is a non-coding RNA molecule that is generated by a process called exon shuffling. In this process, the ORF of the coding gene is randomly split into smaller exons and then reassembled into a new ORF. This process allows the cell to generate unique ORFs by shuffling the genetic material. RPS17P16 is one of the most abundant pseudogenes in the human genome, and it has been identified in various organisms, including humans.

While RPS17P16 is primarily a genetic curiosity, recent studies have suggested that it may also play a role in cellular signaling. Its expression has been observed in various cellular contexts, including the cytoplasm of eukaryotic cells, and it has been involved in the regulation of cellular processes such as cell adhesion, migration, and invasion.

As a drug target, RPS17P16 may be a promising target for small molecule inhibitors that can modulate its activity. This could be useful for treating various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

In addition to its potential as a drug target, RPS17P16 has also been identified as a potential biomarker for various diseases. Its expression has been observed in various disease-related samples, including cancer, neurodegenerative diseases, and autoimmune disorders. By using RPS17P16 as a biomarker, researchers may be able to develop new diagnostic tests for these diseases and monitor disease progress over time.

The Structure and Function of RPS17P16

The structure of RPS17P16 is well conserved across different species, and it has a conserved catalytic core domain that is involved in the binding of small molecules. The conserved catalytic core domain is composed of a characteristic Rossmann-fold that is responsible for the protein's stability and function.

In addition to the conserved catalytic core domain, RPS17P16 also has a unique features that distinguish it from other pseudogenes. One of its most notable features is its ability to transcribe and translate into a functional protein. This is achieved through a process called exon shuffling, which allows the cell to generate a unique ORF by shuffling the genetic material.

Another unique feature of RPS17P16 is its expression pattern. While it is expressed in most eukaryotic cells, its expression is highly variable across different tissues and conditions. For example, it is highly expressed in the cytoplasm of HeLa cells, but its levels are much lower in the nucleus. This variable expression pattern may be a potential target for small molecule inhibitors that can modulate its expression.

Towards a Potential Drug Target

The unique structure and function of RPS17P16 make it an attractive target for small molecule inhibitors. Several studies have suggested that RPS17P16 may play

Protein Name: Ribosomal Protein S17 Pseudogene 16

The "RPS17P16 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RPS17P16 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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