Impact of US3 on Cell Biology and Disease (G6188)

Target Name: RPS3

NCBI ID: G6188

RPS3

Impact of US3 on Cell Biology and Disease

Ribosomal subunit protein uS3 (RPS3) is a protein that plays a critical role in the regulation of gene expression in eukaryotic cells. It is a key component of the small ribosomal subunit (SRU), which is the basic unit of the ribosome that translates mRNA for protein. At work, uS3 combines with the SRU and helps it form. It affects gene expression in a variety of ways, including directly binding to the gene's DNA and affecting SRU assembly and deassembly by binding to DNA-binding proteins.

uS3 plays an important role in cell biology. During protein biosynthesis, SRU is a ribosome-bound protein complex responsible for translating three consecutive nucleotides called "start codons" on the mRNA into protein. SRU is composed of multiple subunits, each with its own function. Among them, uS3 is an important subunit, responsible for helping SRU bind to mRNA and translate it.

In recent years, researchers have discovered that uS3 plays an important role in a variety of diseases, including cancer, neurodegenerative diseases, and immune disorders. For example, studies have found that uS3 levels are associated with prognosis in a variety of cancers, particularly lung and liver cancers. In addition, uS3 levels have been found to be associated with neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease.

Due to its important role in a variety of diseases, uS3 has become an attractive drug target. Researchers are exploring the use of small molecule compounds to inhibit the activity of uS3 to treat these diseases. Additionally, the researchers utilized uS3 as a biomarker to detect disease progression and treatment effectiveness.

Inhibiting uS3 activity may be an effective therapeutic strategy. For example, researchers have found that inhibitors of uS3 can effectively inhibit the growth of cancer cells. This suggests that by inhibiting the activity of uS3, the growth of cancer cells can be significantly inhibited. In addition, the researchers also found that inhibiting uS3 activity can significantly improve the physiological characteristics of neurodegenerative disease models, such as increasing the conduction velocity of the sciatic nerve and reducing neuronal death.

However, inhibiting uS3 activity may also bring about some side effects. For example, studies have found that inhibiting uS3 activity may lead to increased intracellular uS3 levels, thereby increasing intracellular free radical production. This can lead to cell damage and metabolic disorders. Therefore, during the process of inhibiting uS3 activity, possible side effects need to be carefully considered.

In summary, RPS3 (SRU subunit protein uS3) plays an important role in cell biology. It affects gene expression in a variety of ways, including directly binding to the gene's DNA and affecting SRU assembly and deassembly by binding to DNA-binding proteins. In recent years, studies have found that uS3 plays an important role in a variety of diseases, including cancer, neurodegenerative diseases, and immune disorders. Therefore, uS3 has become an attractive drug target. However, during the process of inhibiting uS3 activity, possible side effects need to be carefully considered. Future research will continue to explore the potential of uS3 in treating various diseases and discover more effective treatment strategies.

Protein Name: Ribosomal Protein S3

Functions: Component of the small ribosomal subunit (PubMed:8706699, PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:8706699, PubMed:23636399). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408)

The "RPS3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RPS3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets