RPL4: A Potential Drug Target and Biomarker (G647276)

Target Name: RPL4P4

NCBI ID: G647276

RPL4P4

Other Name(s): ribosomal protein L4 pseudogene 4 | RPL4_2_444 | Ribosomal protein L4 pseudogene 4

RPL4: A Potential Drug Target and Biomarker

Ribosomal protein L4 (RPL4) is a protein that plays a critical role in the regulation of gene expression in eukaryotic cells. It is a large transmembrane protein that contains several unique features, including a unique N-terminus, a characteristic Rossmann-fold, and a distinct C-terminus. RPL4p pseudogene 4 (RPL4P4) is a specific isoform of RPL4 that is expressed in human tissues and has been identified as a potential drug target or biomarker.

Diseease and Therapeutic Potential

RPL4 is involved in various cellular processes, including cell growth, DNA replication, and protein synthesis. It has been implicated in various diseases, including cancer, neurodegenerative diseases, and inherited disorders. RPL4 has also been shown to play a role in the development and progression of diseases, such as Alzheimer's disease and Parkinson's disease.

One of the potential therapeutic applications of RPL4 is its potential as a drug target. RPL4 has been shown to interact with various small molecules, including inhibitors and activators. These interactions may provide a means of targeting RPL4 and modulating its activity to treat various diseases.

In addition to its potential as a drug target, RPL4 has also been shown to be a potential biomarker. The levels of RPL4 have been shown to be altered in various diseases, including cancer, neurodegenerative diseases, and inherited disorders. These changes in RPL4 levels may provide a means of diagnosing and monitoring these diseases.

Expression and Localization

RPL4 is a cytoplasmic protein that is expressed in various tissues and cells of the body. It is primarily expressed in the cytoplasm of eukaryotic cells and is also found in the endoplasmic reticulum (ER) and the nuclear envelope (NE). RPL4 is shown to localize to the endoplasmic reticulum, where it can interact with various nuclear and cytoplasmic proteins.

Function and Interactions

RPL4 is involved in the regulation of protein synthesis and has been shown to interact with various factors that affect protein synthesis, including transcription factors, ribosome subunits, and factors that regulate protein export. It is also involved in the regulation of cell growth and has been shown to play a role in the G1/S transition, a critical step in the cell cycle.

In addition to its role in protein synthesis and cell growth, RPL4 is also involved in the regulation of DNA replication. It has been shown to interact with various DNA replication factors and has been implicated in the regulation of DNA replication in various organisms.

Mutations in RPL4

Mutations in RPL4 have been implicated in the development and progression of various diseases. These mutations can alter the structure and function of RPL4 and affect its ability to interact with various factors. Some mutations, such as those that are associated with the development of cancer, have been shown to have a negative impact on RPL4's activity and function.

Conclusion

RPL4 is a protein that plays a critical role in the regulation of gene expression in eukaryotic cells. Its unique structure and function, as well as its involvement in various cellular processes, make it an attractive target for the development of new drugs or biomarkers for the treatment of various diseases. Further research is needed to fully understand the role of RPL4 in disease and to develop effective treatments based on its unique properties.

Protein Name: Ribosomal Protein L4 Pseudogene 4

The "RPL4P4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RPL4P4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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