RPN2: A Potential Drug Target and Biomarker for Various Diseases

Target Name: RPN2

NCBI ID: G6185

RPN2

RPN2: A Potential Drug Target and Biomarker for Various Diseases

Ribophorin II (RPN2), also known as Transcript variant 4, is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the superfamily of cytoplasmic proteins, which are involved in various cellular processes in eukaryotic cells. One of the unique features of RPN2 is its ability to modulate the activity of microtubules, which are important for cell signaling and transport.

The ribophorin gene is located on chromosome 18 and has four exons. The exons are named RPN2A, RPN2B, RPN2C, and RPN2D, and each exon encodes a unique protein sequence. RPN2A and RPN2B are the protein coding regions, while RPN2C and RPN2D are the non-coding regions that contain introns and exons.

RPN2 is a 21-kDa protein that consists of 135 amino acid residues. It has a molecular weight of 19,312 and a calculated pI of 11.97. RPN2 is expressed in various tissues and organs, including the brain, heart, and kidneys. It is also expressed in the placenta and testes, but at much lower levels than in other tissues.

One of the unique features of RPN2 is its ability to modulate the activity of microtubules. Microtubules are important for cell signaling and transport, and they play a crucial role in the regulation of various cellular processes. RPN2 is involved in the regulation of microtubule dynamics and stability, which is essential for the proper functioning of cells.

In addition to its role in microtubule regulation, RPN2 is also involved in the regulation of various cellular processes, including cell signaling, cell division, and cell survival. It is a component of the endoplasmic reticulum, which is the system for transporting proteins from the cytoplasm to the endoplasmic reticulum. It is also involved in the regulation of the cytoskeleton, which is the system that provides structural support to cells.

RPN2 is a protein that has been identified as a potential drug target in various diseases, including cancer, neurodegenerative diseases, and developmental disorders. Its ability to modulate the activity of microtubules makes it an attractive target for small molecules that can inhibit microtubule activity.

One of the potential benefits of targeting RPN2 is its potential to treat various diseases. For example, RPN2 has been shown to be involved in the regulation of microtubule dynamics, which is essential for the proper functioning of cells. This suggests that targeting RPN2 may be a promising approach for the treatment of various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

In addition to its potential as a drug target, RPN2 is also a potential biomarker for various diseases. Its expression is involved in the regulation of microtubule dynamics, which is a critical factor in the regulation of cellular processes. This suggests that RPN2 may be a useful biomarker for the diagnosis and prognosis of various diseases.

In conclusion, RPN2 is a protein that is expressed in various tissues of the body and is involved in the regulation of microtubule dynamics. Its unique ability to modulate the activity of microtubules makes it an attractive target for small molecules that can inhibit microtubule activity. In addition to its potential as a drug target, RPN2 is also a potential biomarker for various diseases. Further research is needed to fully understand the role of RPN2 in

Protein Name: Ribophorin II

Functions: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity

The "RPN2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RPN2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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