RNA-protein Interactions and G7 Base Methylation in Gene Regulation and Cancer

Target Name: RNMT

NCBI ID: G8731

RNMT

RNA-protein Interactions and G7 Base Methylation in Gene Regulation and Cancer

RNA-protein interactions play a crucial role in various cellular processes, including gene regulation, RNA homeostasis, and protein translation. One of the key players in this process is messenger RNA (mRNA), which carries genetic information from the DNA to the ribosome for protein synthesis. Guanine (G) nucleotides are the most common base pairs in mRNAs, and their methylation status is dynamically regulated to maintain stability and ensure proper translation efficiency.

Guanine 7-methyltransferase (RNMT) is an enzyme that adds a methyl group to the G base in a specific location on the mRNA. This modification affects the stability and translation efficiency of the mRNA, and is crucial for the correct execution of gene expression.

RNMT is a protein that consists of 195 amino acids and has a calculated molecular weight of 21 kDa. It is expressed in various tissues and cells, including muscle, heart, brain, and cancer. The function of RNMT is to add a methyl group to the G base in a specific location on the mRNA, which modifies the stability and translation efficiency of the mRNA.

RNMT has been shown to play a critical role in the regulation of gene expression and cell signaling pathways. It has been implicated in the regulation of muscle growth and development, the development and progression of cancer, and the regulation of neural circuits.

One of the key features of RNMT is its specificity for the G7 position. This means that RNMT adds a methyl group to the G7 base, rather than the G1 or G3 base. The G7 base is the most abundant base in mRNAs, and its methylation status has been shown to play a critical role in the stability and translation efficiency of mRNAs.

RNMT has been shown to add a methyl group to the G7 base in a specific location, known as position -126. This modification has been shown to affect the stability and translation efficiency of mRNAs, and to play a role in the regulation of gene expression.

In addition to its role in the regulation of gene expression, RNMT has also been shown to play a critical role in the development and progression of cancer. In various studies, researchers have shown that RNMT levels are often increased in cancer cells, and that the Methylation status of the G7 base is altered in these cells. These changes in G7 base methylation have been shown to play a critical role in the regulation of cancer cell growth, and in the development and progression of cancer.

In conclusion, RNMT is a protein that plays a critical role in the regulation of gene expression and cell signaling pathways. Its specificity for the G7 position and its role in the regulation of G7 base methylation have been implicated in the development and progression of cancer. Further research is needed to fully understand the role of RNMT in these processes, and to develop effective strategies for targeting this protein as a drug or biomarker.

Protein Name: RNA Guanine-7 Methyltransferase

Functions: Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:9790902, PubMed:9705270, PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871). Binds RNA containing 5'-terminal GpppC (PubMed:11114884)

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