MIR8071-2: A Potential Drug Target and Biomarker (G102466889)

MIR8071-2: A Potential Drug Target and Biomarker

MicroRNA (miRNA) are small non-coding RNAs that play a crucial role in post-transcriptional gene regulation. They are involved in a wide range of cellular processes, including cell growth, apoptosis, and transcriptional regulation. MIR8071-2 is a microRNA that has been identified as a potential drug target and biomarker.

MIR8071-2 is a 21-nt RNA molecule that is derived from the genomic region between the 5' and 3' ends of the gene APOB1926021. It is expressed in various tissues and cells, including brain, heart, liver, and pancreas. MIR8071-2 has a partial melting complementary DNA (PCR) stretch of 192nt, which allows it to be amplified and sequenced.

Several studies have demonstrated that MIR8071-2 plays a role in cell proliferation and apoptosis. For example, MIR8071-2 has been shown to suppress the expression of the genes involved in cell cycle progression and apoptosis, such as the cyclin D1 gene. Additionally, MIR8071-2 has been shown to promote the expression of genes involved in cell survival and angiogenesis, such as the angiogenesis factor PDGF-B gene.

MIR8071-2 has also been shown to play a role in transcriptional regulation. For example, MIR8071-2 has been shown to interact with the protein p21, which is a negative regulator of the cyclin D1 gene. This interaction between MIR8071-2 and p21 suggests that MIR8071-2 may be a positive regulator of the cyclin D1 gene.

In addition to its role in cell proliferation and apoptosis, MIR8071-2 has also been shown to have potential as a drug target. Several studies have shown that MIR8071-2 can be targeted by small molecules, including inhibitors of the protein p21. These inhibitors have been shown to inhibit the interaction between MIR8071-2 and p21, leading to the relaxation of the cyclin D1 gene and increased levels of cyclin D1 protein.

Furthermore, MIR8071-2 has also been shown to be involved in the regulation of cellular processes that are important for human health, such as cancer and cardiovascular disease. For example, MIR8071-2 has been shown to be involved in the regulation of the angiogenesis process, which is important for the development and progression of cancer. Additionally, MIR8071-2 has been shown to be involved in the regulation of the blood-brain barrier, which is important for the delivery of drugs to the brain and the development of neurodegenerative diseases.

In conclusion, MIR8071-2 is a microRNA that has been shown to play a range of roles in cellular processes, including cell proliferation, apoptosis, and transcriptional regulation. Its potential as a drug target and biomarker makes it an attractive target for further research. Further studies are needed to fully understand the role of MIR8071-2 in cellular processes and its potential as a drug.

Protein Name: MicroRNA 8071-2

The "MIR8071-2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MIR8071-2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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