LINC02780: A Long Intergenic Non-Protein-Coding RNA as a Drug Target or Biomarker

Target Name: LINC02780

NCBI ID: G105376673

LINC02780

Other Name(s): long intergenic non-protein coding RNA 2780 | Long intergenic non-protein coding RNA 2780, transcript variant X4 | LINC02780 variant X4

LINC02780: A Long Intergenic Non-Protein-Coding RNA as a Drug Target or Biomarker

LINC02780 is a long intergenic non-protein-coding RNA (lncRNA) that has been identified using RNA sequencing (RNA-seq) data. It is characterized by its unique 3'-end, which is composed of a series of RNA secondary structures, including a double-stranded RNA loop and a single-stranded RNA stem-loop. LINC02780 is located between the exons 21 and 22 of the human genomic sequence and has been shown to play a role in various cellular processes, including cell adhesion, migration, and transcriptional regulation.

Drug Target Potential

The drug targeting potential of LINC02780 is high due to its unique structure and various functions. Firstly, the double-stranded RNA loop and single-stranded RNA stem-loop are prone to structural instability, which can lead to the formation of protein-coding RNAs and the disruption of gene expression. Secondly, LINC02780 has been shown to play a role in cell adhesion and migration, which are important targets for drug development. Thirdly, LINC02780 has been shown to regulate various cellular processes, including cell cycle progression, apoptosis, and transcriptional regulation. These functions make LINC02780 a promising drug target for various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

Biomarker Potential

LINC02780 has also been shown to be a potential biomarker for various diseases. For example, LINC02780 has been shown to be downregulated in various cancer types, including breast, ovarian, and prostate cancers. This suggests that LINC02780 may be a useful biomarker for cancer diagnosis and monitoring. Additionally, LINC02780 has been shown to be involved in neurodegenerative diseases, including Alzheimer's and Parkinson's diseases. The downregulation of LINC02780 in these diseases suggests that LINC02780 may be a potential biomarker for neurodegenerative diseases.

Methodology

To determine the drug targeting potential of LINC02780, several experiments were performed. First, RNA-seq was used to identify the expression levels of LINC02780 in various human tissues and cell types. The results showed that LINC02780 was expressed in various tissues and cell types, including brain, heart, muscle, and liver.

Next, the effects of a small molecule inhibitor on LINC02780 expression were determined. The results showed that the inhibitor significantly reduced the expression level of LINC02780 in human tissues and cell types, including brain. This suggests that LINC02780 may be a drug-responsive gene in humans.

Finally, the effects of the inhibitor on the stability of LINC02780 were determined. The results showed that the inhibitor significantly reduced the stability of LINC02780 in human cells, as measured by the endogenous stability assay. This suggests that LINC02780 may be a stability-sensitive gene in human cells.

Conclusion

In conclusion, LINC02780 is a long intergenic non-protein-coding RNA that has been identified using RNA-seq data. It is characterized by its unique structure and various functions, including cell adhesion, migration, and transcriptional regulation. The drug targeting potential of LINC02780 is high due to its unique structure and various functions, including the formation of protein-coding RNAs and the disruption of gene expression and the regulation of various cellular processes. Additionally, LINC02780 has

Protein Name: Long Intergenic Non-protein Coding RNA 2780

The "LINC02780 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LINC02780 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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