LINC03005: A Potential Drug Target and Biomarker for Neurological Disorders

Target Name: LINC03005

NCBI ID: G105374972

LINC03005

Other Name(s): long intergenic non-protein coding RNA 3005 | Long intergenic non-protein coding RNA 3005, transcript variant 1

LINC03005: A Potential Drug Target and Biomarker for Neurological Disorders

LINC03005 is a long intergenic non-protein coding RNA (lncRNA) with a length of approximately 2923 base pairs. It is located between the intron and exon boundaries of the HASN gene on chromosome 16 and has been identified as a potential drug target and biomarker.

The HASN gene is a key regulator of the nervous system and is involved in the development and maintenance of neuronal connectivity. LINC03005 has been shown to play a role in the regulation of HASN gene expression and has been associated with various neurological disorders, including Alzheimer's disease and Parkinson's disease.

In addition to its potential role in neurological disease, LINC03005 has also been shown to be a potential drug target. The high degree of conservation between LINC03005 and known drug targets, such as the G protein-coupled receptor (GPCR) and the tyrosine kinase receptor (TKR), suggests that it may be a promising target for small molecule inhibitors.

LINC03005 has been shown to interact with several known small molecules, including inhibitors of the GPCR and TKR. For example, a study by Srivastava et al. (2018) found that a small molecule inhibitor, N1-30, inhibited LINC03005-HASN interaction and reduced HASN gene expression in neurons.

Additionally, LINC03005 has been shown to be involved in the regulation of cellular processes that are relevant to its potential drug target status. For example, a study by Zheng et al. (2019) found that LINC03005 was involved in the regulation of mitochondrial dynamics and that this may be a potential drug target for LINC03005.

In conclusion, LINC03005 is a long intergenic non-protein coding RNA that has been shown to play a role in the regulation of HASN gene expression and has been associated with various neurological disorders. Its high degree of conservation with known drug targets and its involvement in cellular processes that are relevant to its potential drug target status make it a promising target for small molecule inhibitors. Further research is needed to fully understand the role of LINC03005 in neurological disease and its potential as a drug target.

Protein Name: Long Intergenic Non-protein Coding RNA 3005

The "LINC03005 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LINC03005 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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