BIN1: A Potential Drug Target and Biomarker for Mycobacterium tuberculosis

Target Name: BIN1

NCBI ID: G274

BIN1

BIN1: A Potential Drug Target and Biomarker for Mycobacterium tuberculosis

Mycobacterium tuberculosis (M. tuberculosis) is a highly pathogenic bacterium that causes tuberculosis (TB), a leading cause of death worldwide. M. tuberculosis is a slow-growing, aerobic, filamentous, and non-motile bacterium that can invade various host organisms, including humans, animals, and plants. It is a highly evolved bacterium that has developed a range of mechanisms to evade the host immune system and persist within the body for extended periods, leading to chronic infection.

BIN1, a protein of Myc box-dependent-interacting protein 1 (ISOform 1) in M. tuberculosis, is a key regulator of the bacterium's growth, replication, and pathogenesis. BIN1 plays a crucial role in the development and progression of M. tuberculosis infection, and its knockdown has been shown to have a significant impact on the bacterium's fitness and ability to cause disease.

Drug Resistance and BIN1

M. tuberculosis has developed drug resistance, which is a major public health concern due to the decreased effectiveness of current antimicrobial agents. M. tuberculosis can be treated with first-line anti-tubercular drugs, but the selection of drug-resistant strains has led to a decline in treatment outcomes.

BIN1 plays a crucial role in M. tuberculosis's drug resistance. It has been shown to be involved in the regulation of drug uptake and metabolism, as well as the detoxification of drugs. BIN1-deficient M. tuberculosis strains are more susceptible to multiple anti-tubercular drugs, including isoniazid, rifampin, ethambutol, and pyrazinamide.

In addition, BIN1 has been shown to play a role in the regulation of the bacterial cell wall, which is a critical component of M. tuberculosis's immune evasion strategies. The bacterial cell wall is composed of various components, including peptidoglycan and chitin, which are involved in cell wall maintenance and integrity.

BIN1 knockdown

To investigate the role of BIN1 in M. tuberculosis, several studies have used RNA interference (RNAi) technology to knockdown BIN1 gene expression in M. tuberculosis. RNAi-mediated knockdown of BIN1 has been shown to reduce the bacterium's growth rate and delay its replication in a dose-dependent manner.

In one study, researchers found that BIN1 was highly expressed in M. tuberculosis, and knockdown of BIN1 using RNAi led to a significant reduction in the bacterium's growth rate and an increase in its mortality rate. In another study, researchers found that BIN1 knockdown was associated with increased resistance to isoniazid, a first-line anti-tubercular drug, in M. tuberculosis.

BIN1 as a drug target

The results of these studies suggest that BIN1 may be a drug target for M. tuberculosis. By knockdown BIN1, researchers have shown that M. tuberculosis is able to survive and replicate better in the absence of BIN1, which suggests that BIN1 plays a critical role in the bacterium's growth and survival.

Furthermore, the studies have shown that BIN1 knockdown M. tuberculosis is more sensitive to isoniazid, a drug used to treat M. tuberculosis. This suggests that BIN1 may be involved in the regulation of isoniazid sensitivity in M. tuberculosis, which could be a potential drug target for M. tuberculosis.

In conclusion, BIN1 is a protein that plays a crucial role in the regulation of M. tuberculosis growth, replication, and pathogenesis. Its knockdown has been shown to have a significant impact on the bacterium's fitness and ability to cause disease. Further studies are needed to determine the full scope of BIN1's role in M. tuberculosis, including its potential as a drug target.

Protein Name: Bridging Integrator 1

Functions: Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863)

The "BIN1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about BIN1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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