BLOC1S2: A Potential Drug Target and Biomarker (G282991)

Target Name: BLOC1S2

NCBI ID: G282991

BLOC1S2

BLOC1S2: A Potential Drug Target and Biomarker

Introduction

BLOC1S2 is a protein that is expressed in various tissues and cells throughout the body. It is a member of the Buyi process family, which includes a variety of proteins that play important roles in the cell cycle. BLOC1S2 plays a key role in cell division, apoptosis, cell signaling, and cell growth regulation.

drug targets

BLOC1S2 is a potential drug target because it is expressed in a variety of tumors. For example, studies have shown that the expression level of BLOC1S2 is significantly increased in lung cancer, liver cancer, and breast cancer. BLOC1S2 is also associated with tumor invasion and metastasis. Therefore, BLOC1S2 may be a promising drug target.

biomarkers

BLOC1S2 is also a potential biomarker that can be used to detect a variety of tumors. For example, studies have shown that in lung cancer, liver cancer, and breast cancer, upregulation of BLOC1S2 can be used to predict tumor invasion and metastasis. In addition, the expression level of BLOC1S2 can also be used to detect tumor apoptosis. Therefore, BLOC1S2 can serve as a promising biomarker.

structure

The structure of BLOC1S2 has been determined. It consists of two domains: N-terminal 伪-helix and C-terminal 尾-coil. The N-terminal 伪-helix is 鈥嬧?媡he main functional domain of BLOC1S2 and is responsible for binding to other proteins. The C-terminal 尾-curl is a secondary functional domain of BLOC1S2 and is responsible for participating in different processes in the cell cycle.

biological functions

BLOC1S2 plays an important role in the cell cycle. It is involved in mitosis and apoptosis in the cell cycle. In mitosis, BLOC1S2 functions on spindle microtubules and is involved in spindle assembly and segregation. In apoptosis, BLOC1S2 participates in the transmission of apoptotic signals on the cell membrane and plays an important role in the regulation of apoptosis.

drug target

BLOC1S2 is a potential drug target because it is expressed in a variety of tumors. For example, studies have shown that the expression level of BLOC1S2 is significantly increased in lung cancer, liver cancer, and breast cancer. BLOC1S2 is also associated with tumor invasion and metastasis. Therefore, BLOC1S2 may be a promising drug target.

biomarker

BLOC1S2 is also a potential biomarker that can be used to detect a variety of tumors. For example, studies have shown that in lung cancer, liver cancer, and breast cancer, upregulation of BLOC1S2 can be used to predict tumor invasion and metastasis. In addition, the expression level of BLOC1S2 can also be used to detect tumor apoptosis. Therefore, BLOC1S2 can serve as a promising biomarker.

in conclusion

BLOC1S2 is a protein that plays an important role in the cell cycle. It is involved in mitosis and apoptosis during the cell cycle and is expressed in a variety of tumors. BLOC1S2 is also associated with tumor invasion and metastasis. Therefore, BLOC1S2 may be a promising drug target and also serve as a promising biomarker.

Protein Name: Biogenesis Of Lysosomal Organelles Complex 1 Subunit 2

Functions: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (PubMed:15102850, PubMed:17182842). In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (By similarity). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). May play a role in cell proliferation (PubMed:15381421)

The "BLOC1S2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about BLOC1S2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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