BOD1: A Potential Drug Target and Biomarker for Chromosomal Abnormalities in Cell Division

Target Name: BOD1

NCBI ID: G91272

BOD1

BOD1: A Potential Drug Target and Biomarker for Chromosomal Abnormalities in Cell Division

Chromosomal abnormalities, such as telomere fusions, copy number variations, and structural rearrangements, are critical events in the regulation of cell division and contribute to the development of various diseases, including cancer. Understanding the role of these genetic changes and their impact on cell behavior is crucial for the development of effective therapeutic strategies. One of the key proteins involved in the regulation of chromosomal abnormalities is BOD1 (Biorientation of chromosomes in cell division protein 1, isoform a), which is a cell-division-specific protein that plays a crucial role in preventing telomere fusion and maintaining chromosomal stability during the cell cycle. In this article, we will explore the potential drug targets and biomarkers associated with BOD1 and its role in the regulation of chromosomal abnormalities.

BOD1: Structure and Function

BOD1 is a 21-kDa protein that is expressed in a variety of tissues, including muscle, heart, and brain. It is a member of the BOD family of proteins, which are involved in the regulation of cell division and homeostasis. BOD1 was identified as a potential drug target due to its involvement in the regulation of chromosomal abnormalities and its expression levels that are altered in various diseases, including cancer.

BOD1 functions as a negative regulator of the telomerase enzyme, which is responsible for maintaining the telomeres on the ends of chromosomes. Telomeres are repetitive DNA sequences that protect the ends of chromosomes from degradation and fusion, and their dysfunction is associated with the aging process and various diseases, including cancer. BOD1 inhibits the activity of telomerase by a mechanism that is distinct from its catalytic activity, which allows it to act as a negative regulator.

In addition to its role in regulating telomerase activity, BOD1 is also involved in the regulation of chromatin structure and dynamics. It has been shown to play a role in the organization of chromatin during the G1 phase of the cell cycle and in the regulation of the transition from G1 to S phase.

Drug Targets and Biomarkers

BOD1 is a potential drug target due to its involvement in the regulation of chromosomal abnormalities and its expression levels that are altered in various diseases, including cancer. Several studies have suggested that BOD1 may be a useful biomarker for monitoring the effectiveness of cancer therapies.

One of the potential drug targets for BOD1 is its role in regulating telomerase activity. Telomerase activity has been shown to be elevated in various types of cancer, including breast and ovarian cancer, and may contribute to the development and progression of these diseases. BOD1 has been shown to inhibit the activity of telomerase, which may represent a potential target for cancer therapies.

Another potential drug target for BOD1 is its role in regulating chromatin structure and dynamics. Chromatin structure and dynamics are critical for the regulation of gene expression and have been implicated in various diseases, including cancer. BOD1 has been shown to play a role in the regulation of chromatin structure and dynamics during the G1 phase of the cell cycle and in the regulation of the transition from G1 to S phase.

Conclusion

In conclusion, BOD1 is a cell-division-specific protein that plays a crucial role in regulating chromosomal abnormalities and has been suggested as a potential drug target for cancer therapies. Its involvement in the regulation of telomerase activity and chromatin structure and dynamics makes it an attractive candidate for further study. Further research is needed to fully understand the role of BOD1 in the regulation of chromosomal abnormalities and its potential as a drug target.

Protein Name: Biorientation Of Chromosomes In Cell Division 1

Functions: Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles

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