IGFBP3: A Potential Drug Target and Biomarker for Tissue Growth and Development

Target Name: IGFBP3

NCBI ID: G3486

IGFBP3

IGFBP3: A Potential Drug Target and Biomarker for Tissue Growth and Development

IGFBP3 (Insulin-like Growth Factor 3) is a protein that plays a critical role in the development and maintenance of tissues, including muscle, bone, and fat. It is a key regulator of cell growth, metabolism, and angiogenesis, and is involved in many diseases, including obesity, diabetes, and cancer.

Recent studies have identified IGFBP3 as a potential drug target and biomarker for a variety of diseases. In this article, we will explore the biology of IGFBP3 and its potential as a drug target.

The IGFBP3 gene is located on chromosome 11 and encodes a 146 amino acid protein. It is a member of the insulin-like growth factor (IGF) family, which includes a variety of proteins that are involved in the regulation of cellular growth and metabolism. IGFBP3 is unique among these proteins in that it has a unique structure that allows it to interact with other proteins in the IGF family.

IGFBP3 is involved in the regulation of cellular processes that are critical for tissue growth and development. It is a key regulator of cell proliferation, cell differentiation, and cell migration. It also plays a role in the regulation of cell metabolism and energy homeostasis.

One of the most significant functions of IGFBP3 is its ability to regulate muscle growth and development. IGFBP3 is expressed in muscle fibers and plays a role in the regulation of muscle cell size, number, and function. It is also involved in the regulation of muscle protein synthesis and degradation.

IGFBP3 is also involved in the regulation of bone development and maintenance. It is a key regulator of bone cell biology and plays a role in the regulation of bone growth, bone resorption, and bone maintenance.

IGFBP3 is also involved in the regulation of fat metabolism. It is a key regulator of lipid metabolism and plays a role in the regulation of fatty acid oxidation and storage.

In addition to its role in tissue regulation, IGFBP3 is also involved in the regulation of cellular signaling pathways. It is a key regulator of the PI3K/Akt signaling pathway, which is involved in the regulation of cellular signaling pathways that are critical for cellular growth, metabolism, and survival.

IGFBP3 is also involved in the regulation of cellular stress responses. It is a key regulator of the DNA damage response and plays a role in the regulation of cellular stress responses.

In conclusion, IGFBP3 is a protein that plays a critical role in the regulation of cellular processes that are essential for tissue growth and development. Its unique structure and functions make it an attractive target for drug development. Further research is needed to fully understand the biology of IGFBP3 and its potential as a drug target.

Protein Name: Insulin Like Growth Factor Binding Protein 3

Functions: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Inhibits the positive effect of humanin on insulin sensitivity (PubMed:19623253). Promotes testicular germ cell apoptosis (PubMed:19952275)

The "IGFBP3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about IGFBP3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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