MIR375: A Potential Drug Target Or Biomarker for Various Diseases
MIR375: A Potential Drug Target Or Biomarker for Various Diseases
MIR375, also known as MIRN375, is a protein that is expressed in various tissues of the body, including the brain, heart, and gastrointestinal tract. It is a member of the microRNA (miRNA) family, which are small non-coding RNAs that play a critical role in post-transcriptional gene regulation.
Recent studies have identified MIR375 as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and gastrointestinal disorders. Its functions and interactions with other molecules have led to a growing interest in its potential as a therapeutic target or diagnostic tool.
MIR375 functions as a negative regulator of microRNA (miRNA) expression in various tissues. It belongs to the miR375 family, which consists of 18 known members. MIR375 is composed of a unique N-terminal region that contains a putative RNA binding domain (RBS ), a core miRNA binding site, and a C-terminal region that contains a conserved GFP-like gene.
The N-terminal region of MIR375 contains a RBS that is similar to those found in other miRNA proteins. This region is known as the \"miR375-RBS\" and is responsible for binding to miR375-containing target miRNAs. The RBS is a crucial region for miRNA function, as it enables the binding of miR375 to its target RNAs.
The core miRNA binding site of MIR375 is located in the middle of the protein and consists of a conserved core loop and a GC-rich region. This region is known as the \"miR375-core\" and is the region where MIR375 interacts with its target miRNAs. The core loop is a critical region for miRNA binding, as it enables the formation of a stable complex between MIR375 and its target miRNA.
The C-terminal region of MIR375 contains a conserved GFP-like gene that is expressed in various tissues of the body. This gene is responsible for producing a protein that can be used as a marker for MIR375 expression in different tissues. The gene is expressed in various tissues, including the brain, heart, and gastrointestinal tract, and has been used to study the functions of MIR375 in these tissues.
Recent studies have identified MIR375 as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and gastrointestinal disorders. Its functions and interactions with other molecules have led to a growing interest in its potential as a therapeutic target or diagnostic tool.
In cancer, MIR375 has been shown to play a negative role in the regulation of microRNA (miRNA) expression. Many studies have shown that MIR375 can inhibit the degradation of miRNAs by targeting the ubiquitin-proteasome pathway. This process is known as \"self -cleaning\" of the miRNA system, and allows MIR375 to maintain high levels of miRNA expression in the cell.
In neurodegenerative diseases, MIR375 has been shown to play a positive role in the regulation of miRNA expression. Studies have shown that MIR375 can enhance the levels of miRNA expression in the brain and that this increase in miRNA expression is associated with the development of neurodegenerative diseases.
In gastrointestinal disorders, MIR375 has been shown to play a positive role in the regulation of miRNA expression. Studies have shown that MIR375 can
Protein Name: MicroRNA 375
The "MIR375 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MIR375 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
MIR376A1 | MIR376A2 | MIR376B | MIR376C | MIR377 | MIR378A | MIR378B | MIR378C | MIR378D1 | MIR378D2 | MIR378E | MIR378F | MIR378G | MIR378H | MIR378I | MIR379 | MIR380 | MIR381 | MIR382 | MIR383 | MIR384 | MIR3907 | MIR3908 | MIR3909 | MIR3910-1 | MIR3910-2 | MIR3911 | MIR3912 | MIR3913-1 | MIR3913-2 | MIR3914-1 | MIR3914-2 | MIR3915 | MIR3916 | MIR3917 | MIR3918 | MIR3919 | MIR3920 | MIR3921 | MIR3922 | MIR3923 | MIR3924 | MIR3925 | MIR3926-1 | MIR3926-2 | MIR3927 | MIR3928 | MIR3929 | MIR3934 | MIR3935 | MIR3936 | MIR3936HG | MIR3937 | MIR3938 | MIR3939 | MIR3940 | MIR3941 | MIR3942 | MIR3943 | MIR3944 | MIR3945 | MIR3945HG | MIR3960 | MIR3972 | MIR3973 | MIR3974 | MIR3976 | MIR3976HG | MIR3977 | MIR3978 | MIR409 | MIR410 | MIR411 | MIR412 | MIR421 | MIR422A | MIR423 | MIR424 | MIR425 | MIR4251 | MIR4252 | MIR4253 | MIR4254 | MIR4255 | MIR4256 | MIR4257 | MIR4258 | MIR4259 | MIR4260 | MIR4261 | MIR4262 | MIR4263 | MIR4264 | MIR4265 | MIR4266 | MIR4267 | MIR4268 | MIR4269 | MIR4270 | MIR4271
