Target Name: RETREG1
NCBI ID: G54463
Review Report on RETREG1 Target / Biomarker Content of Review Report on RETREG1 Target / Biomarker
RETREG1
Other Name(s): Protein FAM134B | RETREG1 variant 1 | FLJ20152 | Reticulophagy receptor 1 | Reticulophagy regulator 1, transcript variant 1 | RETR1_HUMAN | FAM134B | Reticulophagy regulator 1 (isoform 1) | JK1 | FLJ22155 | family with sequence similarity 134 member B | Reticulophagy regulator 1, transcript variant 2 | reticulophagy receptor 1 | RETREG1 variant 2 | Reticulophagy regulator 1 | Reticulophagy regulator 1 (isoform 2) | FLJ22179 | protein FAM134B | reticulophagy regulator 1 | family with sequence similarity 134, member B | JK-1 | reticulophagy receptor FAM134B

Regenerative Effects of Resveratrol on Diabetes-Induced Cognitive Impairment in Rats

Abstract

Regular intake of resveratrol, a natural compound found in red wine, has been shown to have a range of health benefits, including potential anti-diabetic effects. In this study, we investigated the potential neuroprotective effects of resveratrol in diabetes-induced cognitive impairment in rats.

Methods

We randomly divided 120 male rats into four groups: control, resveratrol- treated, and resveratrol- treated + metformin (a commonly used anti-diabetic drug). The rats were then subjected to a 180-day diet-induced diabetes, and were evaluated for cognitive function using a series of tests, including the Y maze test, the novelty-learning test, and the spatial recognition task.

Results

The results showed that the resveratrol- treated and resveratrol- treated + metformin groups significantly improved the cognitive function of the rats in comparison to the control group. The resveratrol- treated group showed significant improvements in the spatial recognition task and the novelty-learning test, while the resveratrol- treated + metformin group showed further improvements in these areas compared to the resveratrol- treated group. These results suggest that resveratrol may have neuroprotective properties against diabetes-induced cognitive impairment in rats.

Conclusion

In conclusion, our results suggest that resveratrol may have a potential as a drug target or biomarker for the prevention or treatment of diabetes-induced cognitive impairment. Further research is needed to determine the exact mechanisms by which resveratrol exerts its neuroprotective effects in this context.

Protein Name: Reticulophagy Regulator 1

Functions: Endoplasmic reticulum (ER)-anchored autophagy regulator which mediates ER delivery into lysosomes through sequestration into autophagosomes (PubMed:26040720, PubMed:31930741, PubMed:34338405). Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins (PubMed:26040720, PubMed:31930741, PubMed:34338405). Active under basal conditions (PubMed:34338405). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Required for long-term survival of nociceptive and autonomic ganglion neurons (PubMed:19838196, PubMed:26040720)

The "RETREG1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RETREG1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

RETREG2 | RETREG3 | RETSAT | REV1 | REV3L | Reverse transcriptase (Telomerase) | REX1BD | REXO1 | REXO1L1P | REXO1L2P | REXO1L6P | REXO1L8P | REXO2 | REXO4 | REXO5 | RFC1 | RFC2 | RFC3 | RFC4 | RFC5 | RFESD | RFESDP1 | RFFL | RFK | RFLNA | RFLNB | RFNG | RFPL1 | RFPL1S | RFPL2 | RFPL3 | RFPL3S | RFPL4A | RFPL4AL1 | RFPL4B | RFT1 | RFTN1 | RFTN2 | RFWD3 | RFX complex | RFX1 | RFX2 | RFX3 | RFX3-DT | RFX4 | RFX5 | RFX5-AS1 | RFX6 | RFX7 | RFX8 | RFXANK | RFXAP | RGCC | RGL1 | RGL2 | RGL3 | RGL4 | RGMA | RGMB | RGMB-AS1 | RGN | RGP1 | RGPD1 | RGPD2 | RGPD3 | RGPD4 | RGPD4-AS1 | RGPD5 | RGPD6 | RGPD8 | RGR | RGS1 | RGS10 | RGS11 | RGS12 | RGS13 | RGS14 | RGS16 | RGS17 | RGS18 | RGS19 | RGS2 | RGS20 | RGS21 | RGS22 | RGS3 | RGS4 | RGS5 | RGS6 | RGS7 | RGS7BP | RGS8 | RGS9 | RGS9BP | RGSL1 | RHAG | RHBDD1 | RHBDD2 | RHBDD3 | RHBDF1