Regenerative Effects of Resveratrol on Diabetes-Induced Cognitive Impairment in Rats
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Regenerative Effects of Resveratrol on Diabetes-Induced Cognitive Impairment in Rats
Abstract
Regular intake of resveratrol, a natural compound found in red wine, has been shown to have a range of health benefits, including potential anti-diabetic effects. In this study, we investigated the potential neuroprotective effects of resveratrol in diabetes-induced cognitive impairment in rats.
Methods
We randomly divided 120 male rats into four groups: control, resveratrol- treated, and resveratrol- treated + metformin (a commonly used anti-diabetic drug). The rats were then subjected to a 180-day diet-induced diabetes, and were evaluated for cognitive function using a series of tests, including the Y maze test, the novelty-learning test, and the spatial recognition task.
Results
The results showed that the resveratrol- treated and resveratrol- treated + metformin groups significantly improved the cognitive function of the rats in comparison to the control group. The resveratrol- treated group showed significant improvements in the spatial recognition task and the novelty-learning test, while the resveratrol- treated + metformin group showed further improvements in these areas compared to the resveratrol- treated group. These results suggest that resveratrol may have neuroprotective properties against diabetes-induced cognitive impairment in rats.
Conclusion
In conclusion, our results suggest that resveratrol may have a potential as a drug target or biomarker for the prevention or treatment of diabetes-induced cognitive impairment. Further research is needed to determine the exact mechanisms by which resveratrol exerts its neuroprotective effects in this context.
Protein Name: Reticulophagy Regulator 1
Functions: Endoplasmic reticulum (ER)-anchored autophagy regulator which mediates ER delivery into lysosomes through sequestration into autophagosomes (PubMed:26040720, PubMed:31930741, PubMed:34338405). Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins (PubMed:26040720, PubMed:31930741, PubMed:34338405). Active under basal conditions (PubMed:34338405). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Required for long-term survival of nociceptive and autonomic ganglion neurons (PubMed:19838196, PubMed:26040720)
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