RNA-Nucleic Acid Factors: Retinoblastoma Proteins and Their Potential Applications

Target Name: RNF4

NCBI ID: G6047

RNF4

RNA-Nucleic Acid Factors: Retinoblastoma Proteins and Their Potential Applications

RNA-Nucleic Acid (RNA) factors are a class of proteins that play a crucial role in various cellular processes. One of the key RNA factors that have gained significant attention in recent years is Retinoblastoma Proteins (RBPs) family member 4 (RNF4).

RNF4 is a 21-kDa protein that is expressed in various tissues, including muscle, heart, and brain. It is a key regulator of gene expression and has been implicated in a wide range of cellular processes, including cell growth, differentiation, and inflammation.

One of the key functions of RFN4 is its ability to interact with DNA to regulate gene expression. RFN4 has been shown to play a role in the regulation of stem cell self-renewal and has been implicated in the development of cancer.

In addition to its role in gene regulation, RFN4 is also a potential drug target. The high degree of sequence variation in the human gene family member 4 gene has made it an attractive target for small molecule inhibitors. Several studies have identified potential inhibitors for RFN4 and have shown that inhibiting RFN4 can lead to significant improvements in cellular and animal models of several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the compounds that has been shown to be an effective inhibitor of RFN4 is 2-fluoro-4-methoxybenzaldehyde (FMBD). FMBD is a small molecule that has been shown to inhibit the activity of RFN4 in cell culture and animal models of disease.

In addition to its potential as a drug inhibitor, RFN4 is also a potential biomarker. The expression of RFN4 has been shown to be elevated in a wide range of cancer samples and has been used as a biomarker for several types of cancer, including breast, lung, and ovarian cancer.

Furthermore, some studies have suggested that RFN4 may play a role in the development of neurodegenerative diseases. For example, one study published in the journal Nature Medicine showed that mice that were genetically modified to lack RFN4 had reduced levels of neurofibrillary tangles and were protected from neurodegeneration.

In conclusion, RNA-Nucleic Acid (RNA) factor Retinoblastoma Proteins (RBPs) family member 4 (RNF4) is a protein that has been shown to play a crucial role in various cellular processes. Its ability to interact with DNA to regulate gene expression and its potential as a drug target make it an attractive target for small molecule inhibitors. Furthermore, RFN4 has also been shown to be a potential biomarker for several types of cancer and neurodegenerative diseases. Further research is needed to fully understand the role of RFN4 in these processes and to develop effective treatments.

Protein Name: Ring Finger Protein 4

Functions: E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation (PubMed:18408734, PubMed:19307308, PubMed:35013556). Regulates the degradation of several proteins including PML and the transcriptional activator PEA3 (PubMed:18408734, PubMed:19307308, PubMed:20943951). Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation (PubMed:20212317). Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1 (PubMed:19779455, PubMed:20026589). Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation (PubMed:12885770). Catalyzes ubiquitination of sumoylated PARP1 in response to PARP1 trapping to chromatin, leading to PARP1 removal from chromatin by VCP/p97 (PubMed:35013556)

The "RNF4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RNF4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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