Unlocking the Potential of LIN7B: A proteinlin-7 Homolog B (ISO Form 1) as a Drug Target and Biomarker

Target Name: LIN7B

NCBI ID: G64130

LIN7B

Unlocking the Potential of LIN7B: A proteinlin-7 Homolog B (ISO Form 1) as a Drug Target and Biomarker

Proteinlin-7 (PL-7) is a highly conserved protein that plays a crucial role in various cellular processes. It is a key regulator of cell adhesion, migration, and invasion, and has been implicated in numerous diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. The protein encoded by the LIN7 gene, also known as LIN7B, is a key isoform that has been extensively studied for its unique function in various cellular processes. In this article, we will explore the potential of LIN7B as a drug target and biomarker.

Drug Target Potential

LIN7B is a protein that has been targeted by several drugs in the treatment of various diseases. Its unique structure and function make it an attractive drug target. One of the main reasons for targeting LIN7B is its role in cell adhesion and migration. LIN7B has been shown to regulate the migration of cancer cells to new sites, and is also involved in the regulation of normal cell migration during development and wound healing.

In addition to its role in cell adhesion and migration, LIN7B has also been shown to play a key role in the regulation of cell signaling pathways. It has been shown to interact with several signaling molecules, including TGF-β, Wnt, andNotch. These interactions have been implicated in the regulation of cellular processes such as cell growth, differentiation, and survival.

Biomarker Potential

LIN7B has also been shown to be a potential biomarker for several diseases. Its unique function in the regulation of cell signaling pathways makes it an attractive target for biomarker development. For example, LIN7B has been shown to be involved in the regulation of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

In addition to its potential as a biomarker, LIN7B has also been shown to be involved in the regulation of cancer. Its role in cell adhesion and migration has been implicated in the development and progression of several types of cancer, including breast, ovarian, and prostate cancer.

Expression and Modulation

LIN7B is a highly conserved protein that is expressed in a variety of tissues and cells. Its expression has been shown to be regulated by several factors, including tissue type, developmental stage, and signaling pathways.

One of the key factors that regulates LIN7B expression is its phosphorylation state. LIN7B has several potential phosphorylation sites, including Ser-235, Thr-236, and Tys-238. These sites have been shown to play important roles in the regulation of LIN7B function.

In addition to its phosphorylation state, LIN7B has also been shown to be regulated by several other factors, including DNA methylation, histone modification, and post-translational modification.

Conclusion

In conclusion, LIN7B is a protein that has been extensively studied for its unique function in various cellular processes. Its unique structure and function make it an attractive drug target and biomarker. The regulation of LIN7B expression and function by several factors, including its phosphorylation state, DNA methylation, histone modification, and post-translational modification, makes it a promising target for drug development. Further research is needed to fully understand the function of LIN7B and its potential as a drug target and biomarker.

Protein Name: Lin-7 Homolog B, Crumbs Cell Polarity Complex Component

Functions: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity)

The "LIN7B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LIN7B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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