LINC00354: A Non-Protein-Coding RNA Molecule with Potential as a Drug Target

Target Name: LINC00354

NCBI ID: G101928616

LINC00354

Other Name(s): Long intergenic non-protein coding RNA 354, transcript variant 1 | long intergenic non-protein coding RNA 354

LINC00354: A Non-Protein-Coding RNA Molecule with Potential as a Drug Target

LINC00354 is a non-protein coding RNA (ncRNA) molecule located within the intron of the gene ZNF21. It is a potential drug target and has been identified as a potential biomarker for several diseases, including cancer.

The ZNF21 gene is a member of the TCF-ZNF family, which is known for their role in regulating gene expression and cell development. The ZNF21 gene is expressed in various tissues and cells of the body, including fetal brain, placenta, and tissues of the central nervous system. It is also highly expressed in human cancer tissues, making it a potential target for cancer therapies.

LINC00354 is a non-coding RNA molecule that is located within the intron of the ZNF21 gene. It is characterized by a unique structure that consists of a stem-loop and a terminal exon. The stem-loop region of LINC00354 is composed of a series of alternating G/C and A/T base pairs, while the terminal exon is composed of a single A base pair.

The G/C and A/T base pairs in the stem-loop region of LINC00354 correspond to a specific secondary structure, known as a double-stranded RNA loop. This loop is composed of a series of base pairs that form a closed double-stranded structure, which is stable enough to support the stability of the stem-loop region.

The terminal exon region of LINC00354 is composed of a single A base pair, which is the exon that is responsible for transmitting the genetic information from the ZNF21 gene to the cell. This exon is usually expressed in RNAi knockdown experiments as a reference gene, as it is not predicted to have any functional consequences in the absence of the ZNF21 gene.

LINC00354 has been identified as a potential drug target and biomarker due to its unique structure and expression patterns in various tissues of the body. The high expression level of LINC00354 in cancer tissues, as well as its unique secondary structure, suggest that it may play a role in the regulation of gene expression and cell development.

In addition, LINC00354 has also been shown to have protein-coding potential. Using microarray analysis, researchers have identified several highly expressed proteins that contain exons that are similar to those in LINC00354. These proteins may function as potential negative regulators of LINC00354, helping to ensure that it is not expressed at high levels and potentially contributing to the development of cancer.

Overall, LINC00354 is a non-protein coding RNA molecule that is located within the intron of the ZNF21 gene. Its unique structure and high expression level in various tissues of the body make it a potential drug target and biomarker for several diseases, including cancer. Further research is needed to determine the exact function of LINC00354 and its potential as a therapeutic target.

Protein Name: Long Intergenic Non-protein Coding RNA 354

The "LINC00354 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LINC00354 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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