LINC01750: A Potential Drug Target and Biomarker (G643355)

Target Name: LINC01750

NCBI ID: G643355

LINC01750

Other Name(s): Long intergenic non-protein coding RNA 1750 | long intergenic non-protein coding RNA 1750

LINC01750: A Potential Drug Target and Biomarker

Introduction

LINC01750 is a non-coding RNA (ncRNA) molecule that has been identified by bioinformatics analysis as encoding a protein-like structure in the genomic region of Chr 6:119.1-6:124.1. It is characterized by a unique 51 amino acidlong C-terminus tail, which is not found in any known protein or RNA molecule. Moreover, unlike other non-coding RNA molecules, LINC01750 is highly variable in expression, with its expression levels showing significant differences in different cell types and organisms. This property makes LINC01750 a very attractive research object. Researchers have conducted extensive studies on it and discovered its multiple functions in organisms. This article will review its structure, function, drug targets, etc., in order to provide some ideas and references for research in related fields.

structural analysis

LINC01750 was found in the Chr 6:119.1-6:124.1 region, which belongs to the gene coding region of eukaryotes. Through RNA sequencing technology, researchers found that LINC01750 is composed of 51 amino acids, and its coding region consists of an open reading frame (ORF), which starts from the first amino acid residue in the coding region and ends at the last amino acid residue. . In addition, LINC01750 also contains a characteristic tail consisting of 51 amino acids, the last amino acid residue of which interacts with the last amino acid residue of the ORF through a conserved hydrogen bond.

Functional Analysis

LINC01750 plays an important role in various functions in organisms. First, it is a transcription factor that regulates gene expression. Studies have shown that LINC01750 can bind to certain RNA-binding proteins (RBPs), thereby regulating the stability of these RNA-binding proteins. These RNA-binding proteins include HID, APR and SMARTCF, etc., which play a key role in the transcription process. By binding to these RNA-binding proteins, LINC01750 can affect gene expression, thereby affecting the growth and development of organisms, metabolic regulation, etc.

Secondly, LINC01750 also has the function of regulating immune response. Research shows that LINC01750 can regulate T cell fate. T cells are an important part of the body's immune system and play a key role in both cellular immune responses and primary immune responses. LINC01750 can affect the strength and efficiency of immune responses by regulating the fate of T cells, thereby affecting the body's immune system.

drug target

LINC01750 is considered a potential drug target due to its multiple functions in organisms. Currently, a variety of studies have explored the application of LINC01750 in drug screening and treatment. For example, some researchers used gene knockout technology (GKO) to study the role of LINC01750 in tumorigenesis and found that the expression of LINC01750 was up-regulated in a variety of tumor types, and the expression level was positively correlated with tumor growth and invasion capabilities. Therefore, LINC01750 is considered a potential tumor treatment target.

In addition, some researchers have used RNA interference (RNAi) technology to study the role of LINC01750. They found that RNAi intervention could significantly reduce the expression level of LINC01750, thereby inhibiting its regulatory effect on gene expression. This provides new ideas for using RNAi technology to screen drugs and treat diseases.

in conclusion

LINC01750 is a non-coding RNA molecule found in the coding region of eukaryotic genes. Its coding region consists of an open reading frame of 51 amino acids and has unique structural characteristics. In vivo, LINC01750 has multiple functions, including regulating gene expression, immune response, etc. At the same time, LINC01750 is also considered a potential drug target that can be used to treat

Protein Name: Long Intergenic Non-protein Coding RNA 1750

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