LINC00488: A Long Intergenic Non-Protein-Coding RNA as a Drug Target and Biomarker

Target Name: LINC00488

NCBI ID: G677779

LINC00488

Other Name(s): Long intergenic non-protein coding RNA 488 | C3orf66 | long intergenic non-protein coding RNA 488

LINC00488: A Long Intergenic Non-Protein-Coding RNA as a Drug Target and Biomarker

Introduction

LINC00488 is a long intergenic non-protein-coding RNA (lncRNA) that has been identified in various organisms, including humans. It is characterized by its unique 5'-end cap structure of approximately 1,200 nucleotides, and its stability secondary structure. LINC00488 plays an important role in biological processes such as gene expression regulation, cell cycle, and DNA damage repair. At the same time, LINC00488 is also considered a potential drug target and biomarker. This article will review the structure, function, drug targets and potential applications of LINC00488.

1. Structural characteristics

The full length of LINC00488 is approximately 290 nucleotides, and its 5'-end contains a cap structure. The cap structure consists of a 7-nt antisense RNA sequence and a poly (A/T) tail. This structure allows LINC00488 to have good stability within cells and resist damage by the RNA degradation pathway to a certain extent. The secondary structure of LINC00488 is mainly composed of polynucleotide sequences at the 3' end and 5' end, showing a right-handed helical structure.

2. Functional analysis

LINC00488 plays an important role in the regulation of gene expression. Studies have shown that LINC00488 can bind to some transcription factors, such as RNA polymerase II (RNA-II), RNA-induced gene expression (RNA-GE), transcription factor binding protein (TBP), etc. These binding events may have effects on gene expression, thereby affecting biological processes such as cell cycle, proliferation, differentiation, and tumorigenesis. In addition, LINC00488 also plays a role in DNA damage repair. Studies have shown that LINC00488 can bind to DNA polymerase I (DNA-PAI) and promote DNA repair when DNA double strands are damaged.

3. Drug Targets

As a non-protein-coding RNA, LINC00488's unique three-dimensional structure makes it a potential drug target. At present, a variety of drugs have been proven to be able to bind to the cap structure of LINC00488, such as acetylated small molecules, cyclophosphamide, etc. In addition, the secondary structure of LINC00488 also makes it possible to become a binding partner that can interact with proteins to regulate various biological processes in cells.

4. Potential applications

As a new type of non-protein-coding RNA, LINC00488's unique structure and function make it a potential drug target. At the same time, LINC00488's role in biological processes such as gene expression regulation and DNA damage repair also provides a theoretical basis for its biomarker development. In the future, LINC00488, as a drug target, will be widely used in drug development and disease treatment.

Protein Name: Long Intergenic Non-protein Coding RNA 488

The "LINC00488 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LINC00488 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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