LINC00498: A Long Intergenic Non-Protein Coding RNA and Its Potential as a Drug Target

Target Name: LINC00498

NCBI ID: G105377446

LINC00498

Other Name(s): Long intergenic non-protein coding RNA 498, transcript variant X1 | long intergenic non-protein coding RNA 498 | LINC00498 variant X1

LINC00498: A Long Intergenic Non-Protein Coding RNA and Its Potential as a Drug Target

Introduction

LINC00498 is a long intergenic non-protein coding RNA (lncRNA) with a length of approximately 2100 nucleotides. It is found in various organisms, including humans, and is characterized by its ability to interact with proteins, which results in its potential involvement in various cellular processes. LINC00498 has been identified as a potential drug target and has been the subject of intense research in the field of gene regulation and disease.

Structure and Expression

The structure of LINC00498 is conserved across various organisms, with a conserved core region upstream of the first exon followed by a variable region that includes several conserved motifs, such as a GASN conserved motif and a TUDOR conserved motif. The variable region includes a A putative RNA-binding protein (RBP) binding site, a presumed binding site for RNA-binding proteins, and a conserved RNA-binding site, a presumed binding site for RNA-binding proteins.

Expression and Function

LINC00498 is highly expressed in various tissues and organs, including brain, heart, liver, and muscle. It has been shown to be involved in various cellular processes, including cell adhesion, migration, and survival. LINC00498 has also been shown to play a role in the development and progression of various diseases, including cancer and neurodegenerative diseases.

Drug Interaction with LINC00498

Several studies have demonstrated that LINC00498 can be targeted by small molecules, including inhibitors of RNA binding proteins. One such inhibitor, XML0102, has been shown to reduce the expression of LINC00498 in various tissues and cells, including cancer cells. Other studies have also shown that LINC00498 can be targeted by small molecules that target the RNA binding activity of LINC00498, such as small molecules that inhibit the activity of RNA binding proteins.

Conclusion

In conclusion, LINC00498 is a long intergenic non-protein coding RNA that has been identified as a potential drug target due to its involvement in various cellular processes and its association with various diseases. The conservation of its structure and the expression of its variable region make it a promising target for small molecules. Further research is needed to fully understand the role of LINC00498 as a drug target and to develop effective therapies for the treatment of diseases associated with its dysfunction.

Protein Name: Long Intergenic Non-protein Coding RNA 498

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•   general information;
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•   the target screening and validation;
•   expression level;
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