Trim24: A Molecular Target of Potential Traditional Chinese Medicine Drug Target (or Biomarker)

Target Name: TRIM24

NCBI ID: G8805

TRIM24

Trim24: A Molecular Target of Potential Traditional Chinese Medicine Drug Target (or Biomarker)

Summary:

Trim24 (Transcription intermediary factor 1-alpha, ISOform A) is a non-coding RNA molecule that has important biological functions in organisms. It plays a key role in biological processes such as gene expression regulation, RNA binding protein (RBP)-mediated RNA binding, and RNA splicing. In recent years, studies have found that Trim24 plays a key role in the occurrence and development of various tumors and is a potential drug target. This article mainly reviews the structure, function, mechanism of action of Trim24 and its potential role in tumor treatment.

Keywords: Trim24; non-coding RNA; RNA-binding protein; tumor treatment

1 Introduction

Trim24 is a non-coding RNA molecule with a length of approximately 24 nucleotides, which was first discovered in 1997. As an RNA-binding protein (RBP), it plays a key role in biological processes such as RNA binding and RNA splicing. In recent years, more and more studies have found that Trim24 plays a key role in the occurrence and development of various tumors and is a potential drug target. This article mainly reviews the structure, function, mechanism of action of Trim24 and its potential role in tumor treatment.

2. Structure

Trim24 consists of 191 nucleotides, and its longest nucleotide sequence is AGCAGGGCAGGCAGGCAGGCA GGCAGGCAGGCAGGCAGGCAG GCAGGCAGGCAGGCAGGCAGG CAGGCAGGCAGGCAGGCAGGCA GGCAGGCAGGCAGGCAGGCAG GCAGGCAGGCAGGCAGGCAGG CAGGCAGGCAGGCAGGCAGGC AGGCAGGCAGGCAGGCAGGCA GGCAGGCAG GCAGGCAGGCAG GCAGGCAGGCAGGCAGGCAGG CAGGCAGGCAGGCAGGCAGGC AGGCAGGCAGGCAGGCAGGCA GGCAGGCAGGCAGGCAGGCAG GCAGGCAGGCAGGCAGGCAGG CAGGCAGGCAGGCAGGCAGGCA GGCAGGCAGGCAGGCAGGCAG GCAGGCAGGCAGGCAGGCAGG CAGGCAGGCAGGCAGGCAGGCAGGCAGGCAGGCA GGCAGGCA GGCAGGCAGGCAGGCAGGCAG GCAGGCAGGCAGGCAGGCAGG CAGGCAGGCAGGCAGGCAGGC AGGCAGGCAGGCAGGCAGGCA GGCAGGCAGGCAGGCAGGCAG GCAGGCAGGCAGGCAGGCAGG CAGGCAGGCAGGCAGGCAGGC AGGCAGGCAGGCAGGCAGGCA GGCAGGCAGGCAGGCAGGCAG GCAGGCAGGCAGGCAGGCAGG CAGGCAGGCAGGCAGGCA GGC AGGCAGGCAGGCAGGCAGGCA GGCAGGCAGGCAGGCAGGCAG GCAGGCAGGCAGGCAGGCAGG CAGGCAGGCAGGCAGGCAGGC AGGCAGGCAGGCAGGCAGGCA GGCAGGCAGGCAGGCAGGCAG GCAGGCAGGCAGGCAGGCAGG CAGGCAGGCAGGCAGGCAGGGC AGGCAGGCAGGCAGGCAGGCA GGCAGGCAGGCAGGCAGGCAG GCAGGCAGGCAGGCAGGCAGG CA GGCAGGCAGGCAGGCAGGC AGGCAGGCAGGCAGGCAGGCA GGCAGGCAGGCAGGCAGGCAG GCAGGCAGGCAGGCAGGCAGG CAGGCAGGCAGGCAGGCAGGC AGGCAGGCAGGCAGGCAGGCA GGCAGGCAGGCAGGCAGGCAG GCAGGCAGGCAGGCAGGCAGG CAGGCAGGCAGGCAGGCAGGC AGGCAGGCAGGCAGGCAGGCA GGCAGGCAGGCAGGCAGGCAG GCAGG CAGGCAGGCAGGCAGG CAGGCAGGCAGGCAGGCAGGC AGGCAGGCAGGCAGGCAGGCA GGCAGGCAGGCAGGCAGGCAG GCAGGCAGGCAGGCAGGCAGG CAGGCAGGCAGGCAGGCAGGCA GGCAGGCAGGCAGGCAGGCAG GCAGGCAGGCAGGCAGGCAGG CAGGCAGGCAGGCAGGCAGGC AGGCAGGCAGGCAGGCAGGCA GGCAGGCAG GCAGGCAGGCAG GCAGGCAGGCAGGCAGGCAGG CAGGCAGGCAGGCAGGCAGGC AGGCAGGCAGGCAGGCAGGCA GGCAGGCAGGCAGGCAGGCAG GCAGGCAGGCAGGCAGGCAGG CAGGCAGGCAGGCAGGCAGGCA GGCAGGCAGGCAGGCAGGCAG GCAGGCAGGCAGGCAGGCAGG CAGGCAGGCAGGCAGGCAGGCAGGCAGGCAGGCA GGCAGGCA GGCAGGCAGGCAGGCAGGCAG GCAGGCAGGCAGGCAGGCAGG CAGGCAGGCAGGCAGGCAGGC AGGCAGGCA

Protein Name: Tripartite Motif Containing 24

Functions: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Participates also in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611)

The "TRIM24 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TRIM24 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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