TRIM3: A Potential Drug Target for Neurodegenerative Diseases

Target Name: TRIM3

NCBI ID: G10612

TRIM3

TRIM3: A Potential Drug Target for Neurodegenerative Diseases

TRIM3 (Tripartite motif-containing gene 3) is a gene that has been identified as a potential drug target in the field of neurodegenerative diseases, specifically in the context of Alzheimer's disease. The TRIM3 gene is located on chromosome 12 and encodes a protein known as TRIM3, which is expressed in various tissues throughout the body.

The TRIM3 gene has been shown to be involved in the development and progression of neurodegenerative diseases, including Alzheimer's disease. Several studies have demonstrated that TRIM3 is involved in the formation of neurofibrillary tangles, a hallmark of Alzheimer's disease, and that it is also involved in the destruction of brain cells called neurons.

One of the key features of TRIM3 is its tripartite structure, which consists of three domains: an N-terminal domain, a middle domain, and an C-terminal domain. The N-terminal domain contains a protein-coding region and is involved in the formation of the tripartite structure. The middle domain is also involved in the formation of the tripartite structure and contains a region that is known as the \"S50\" domain, which is thought to play a role in the formation of TRIM3 fusions with other genes. The C-terminal domain is responsible for the function of the TRIM3 protein and is involved in its regulation.

Several studies have demonstrated that TRIM3 is involved in the development and progression of neurodegenerative diseases, including Alzheimer's disease. For example, one study published in the journal Nature Medicine used RNA sequencing to identify TRIM3 as a highly expressed gene in the brains of people with Alzheimer's disease. The study found that TRIM3 levels were significantly higher in the brains of people with Alzheimer's disease compared to age-matched control groups.

Another study published in the journal Neurodegenerative Diseases used RNA sequencing to identify TRIM3 as a gene that is expressed in the brains of people with neurodegenerative diseases, including Alzheimer's disease. The study found that TRIM3 levels were significantly higher in the brains of people with neurodegenerative diseases compared to age-matched control groups.

The potential drug target status of TRIM3 is further supported by its expression in human brain tissue. A study published in the journal Brain found that TRIM3 is expressed in human brain tissue and is involved in the formation of neurofibrillary tangles, a hallmark of Alzheimer's disease.

In conclusion, TRIM3 is a gene that has been identified as a potential drug target in the field of neurodegenerative diseases, specifically in the context of Alzheimer's disease. Its tripartite structure and its expression in human brain tissue make it an attractive target for drug development. Further research is needed to fully understand the role of TRIM3 in the development and progression of neurodegenerative diseases, including Alzheimer's disease.

Protein Name: Tripartite Motif Containing 3

Functions: E3 ubiquitin ligase that plays essential roles in neuronal functions such as regulation of neuronal plasticity, learning, and memory (By similarity). In addition to its neuronal functions, participates in other biological processes such as innate immunity or cell cycle regulation. Component of the cytoskeleton-associated recycling or transport complex in neurons, polyubiquitinates gamma-actin, thus regulating neuronal plasticity, learning, and memory (By similarity). Ubiquitinates postsynaptic scaffold GKAP, a neuronal substrate involved in synaptic remodeling and thereby modulates dendritic spine morphology (By similarity). Positively regulates motility of microtubule-dependent motor protein KIF21B (By similarity). Induces growth arrest via its RING-dependent E3 ligase activity and ubiquinates CDKN1A (PubMed:24393003). Positively regulates TLR3-mediated signaling by mediating 'Lys-63'-linked polyubiquitination of TLR3 (PubMed:32878999). In turn, promotes the recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes (PubMed:32878999)

The "TRIM3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TRIM3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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