LINC01645: A Long Intergenic Non-Protein Coding RNA as a Drug Target or Biomarker

Target Name: LINC01645

NCBI ID: G102724661

LINC01645

Other Name(s): long intergenic non-protein coding RNA 1645 | Long intergenic non-protein coding RNA 1645

LINC01645: A Long Intergenic Non-Protein Coding RNA as a Drug Target or Biomarker

LINC01645 is a long intergenic non-protein coding RNA (lncRNA) that has been identified in various studies as a potential drug target or biomarker. It is a non-coding RNA molecule that is located between the coding regions of two closely located genes, LINC01639 and LINC01652, on chromosome 6p12. LINC01645 is unique due to its unusual structure, length, and expression pattern.

Structure and Expression

The structure of LINC01645 is highly conserved across different species, which indicates that it may have a critical role in gene regulation. It has a unique 5'-end that is composed of a single exon followed by a variable number of exons (up to 12) that are involved in the formation of a stem-loop structure. The stem-loop region is responsible for the formation of a stable double-stranded RNA structure that can interact with other non-coding RNAs and proteins.

Expression of LINC01645 is highly variable among different tissues and cell types. It is expressed in various tissues, including brain, heart, muscle, liver, and pancreas, and has been shown to be involved in various biological processes, including cell growth, differentiation, and regulation of gene expression.

Drug Target Potential

LINC01645 is a good candidate for a drug target due to its unique structure and expression pattern. The conserved nature of its structure suggests that it may have a similar function to other non-coding RNAs that have been drug targets, such as RNA interference (RNAi) agents. These agents work by binding to specific non-coding RNAs and causing them to be degraded.

One of the challenges in drug targeting non-coding RNAs is the difficulty in predicting their target molecules. However, LINC01645 may be a good candidate for drug targeting due to its unique expression pattern and the fact that it is located between two closely located genes that have been implicated in various diseases, including cancer and neurological disorders.

Biomarker Potential

LINC01645 may also be a useful biomarker for various diseases, including cancer. Its unique expression pattern and location between two closely located genes make it an attractive candidate for cancer diagnosis and monitoring. For example, LINC01645 has been shown to be downregulated in various types of cancer, which suggests that it may be a potential therapeutic target.

Conclusion

In conclusion, LINC01645 is a long intergenic non-protein coding RNA that has unique structure and expression pattern. Its conserved nature and location between two closely located genes make it a potential drug target or biomarker. Further research is needed to determine its function and potential as a therapeutic target or biomarker.

Protein Name: Long Intergenic Non-protein Coding RNA 1645

The "LINC01645 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LINC01645 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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