A Potential Drug Target: LOC105378019 (G105378019)

A Potential Drug Target: LOC105378019

Introduction

LOC105378019 is a protein that is expressed in various tissues of the body, including the brain. Its function and structure have been annotated, and it has been implicated in several diseases, including neurodegenerative disorders, depression, and cancer. The potential drug target, LOC105378019 , is an attractive target for drug development due to its unique structure and the diseases it is associated with.

Structure and Function

LOC105378019 is a protein that contains 19 distinct domains. The protein has a molecular weight of 21 kDa and a pre-protein N-terminal extension of 14 amino acids. It has a distinct N-terminus that contains a conserved basic amino acid sequence (VAL -GLU-ASP-SER-TAA-ASP-VAL) and a C-terminus that contains a conserved glycine-rich region (GY-GLN-ASP-ASP-TAA-ASP-GY).

LOC105378019 is a glycoprotein that consists of two distinct structural domains: the N-terminal domain and the C-terminal domain. The N-terminal domain is responsible for the protein's monomeric structure and functions as a scaffold, while the C-terminal domain interacts with other proteins and plays a role in the protein's stability.

The N-terminus of LOC105378019 contains a conserved basic amino acid sequence that is involved in the formation of a hydrogen bond with the adjacent alpha-helix. This interaction between the N-terminus and the alpha-helix is ??????important for the protein's stability and functions as a monomer.

The C-terminus of LOC105378019 contains a conserved glycine-rich region that is involved in the formation of a disulfide bond with the adjacent alpha-helices. This interaction between the C-terminus and the alpha-helices is important for the protein's stability and functions as a monomer.

LOC105378019 is expressed in various tissues of the body, including the brain, and has been implicated in several diseases, including neurodegenerative disorders, depression, and cancer. The expression of LOC105378019 is also associated with several diseases, including Alzheimer's disease, Parkinson's disease, and depression.

Drug Targeting

LOC105378019 is a potential drug target due to its unique structure and the diseases it is associated with. The N-terminus and C-terminus of LOC105378019 contain conserved amino acid sequences that are involved in the formation of hydrogen bonds and disulfide bonds, which may be important for the protein's stability and functions as a monomer. Therefore, small molecules that can modulate these interactions may be useful drug targets.

One approach to drug targeting LOC105378019 is to use small molecules that can modulate the interaction between the N-terminus and the alpha-helix. One example of such a small molecule is known as L-741, which is a potent inhibitor of the protein tyrosine Kinase (PTK). L-741 is able to inhibit the phosphorylation of LOC105378019 at its N-terminus, which can modulate the interaction between the N-terminus and the alpha-helix.

Another approach to drug targeting LOC105378019 is to use small molecules that can modulate the interaction between the C-terminus and the alpha-helices. One example of such a small molecule is known as D-874, which is a potent inhibitor of the protein

Protein Name: Uncharacterized LOC105378019

The "LOC105378019 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LOC105378019 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

LOC105378022 | LOC105378058 | LOC105378066 | LOC105378072 | LOC105378082 | LOC105378085 | LOC105378088 | LOC105378091 | LOC105378099 | LOC105378105 | LOC105378110 | LOC105378120 | LOC105378145 | LOC105378146 | LOC105378150 | LOC105378178 | LOC105378189 | LOC105378204 | LOC105378206 | LOC105378228 | LOC105378305 | LOC105378310 | LOC105378314 | LOC105378316 | LOC105378318 | LOC105378327 | LOC105378334 | LOC105378335 | LOC105378339 | LOC105378340 | LOC105378342 | LOC105378347 | LOC105378409 | LOC105378414 | LOC105378460 | LOC105378477 | LOC105378486 | LOC105378492 | LOC105378502 | LOC105378508 | LOC105378515 | LOC105378517 | LOC105378520 | LOC105378525 | LOC105378526 | LOC105378537 | LOC105378543 | LOC105378559 | LOC105378560 | LOC105378586 | LOC105378589 | LOC105378596 | LOC105378605 | LOC105378606 | LOC105378617 | LOC105378641 | LOC105378654 | LOC105378657 | LOC105378663 | LOC105378678 | LOC105378693 | LOC105378694 | LOC105378741 | LOC105378750 | LOC105378761 | LOC105378764 | LOC105378776 | LOC105378780 | LOC105378793 | LOC105378797 | LOC105378798 | LOC105378800 | LOC105378841 | LOC105378856 | LOC105378867 | LOC105378901 | LOC105378917 | LOC105378920 | LOC105378977 | LOC105378980 | LOC105378987 | LOC105379003 | LOC105379007 | LOC105379011 | LOC105379030 | LOC105379031 | LOC105379044 | LOC105379053 | LOC105379055 | LOC105379078 | LOC105379082 | LOC105379083 | LOC105379093 | LOC105379103 | LOC105379105 | LOC105379107 | LOC105379109 | LOC105379117 | LOC105379118 | LOC105379130