LINC02778: A Long Intergenic Non-Protein Coding RNA and a Potential Drug Target

Target Name: LINC02778

NCBI ID: G105378760

LINC02778

Other Name(s): long intergenic non-protein coding RNA 2778 | Long intergenic non-protein coding RNA 2778

LINC02778: A Long Intergenic Non-Protein Coding RNA and a Potential Drug Target

Introduction

LINC02778 is a long intergenic non-protein coding RNA (lncRNA) that has been identified in various organisms, including humans. It is characterized by its unique structure, which consists of a series of alternating exons derived from different genic regions. LINC02778 has been shown to play a role in various cellular processes, including cell adhesion, migration, and tissue repair. Its function and potential as a drug target are of great interest for the development of new therapeutic approaches.

Structure and Expression

LINC02778 is a 24.9 kilobase (kb) RNA molecule with a +-strand structure. It consists of 10 exons, which are arranged in a alternating order, as determined by the reading frame. The first exon is a 5'-end exon, while the last exon is a 3'-end exon. The exons are named based on their position within the reading frame, with the first exon being exon 1.

LINC02778 was first identified using RNA sequencing (RNA-seq) data from the human transcriptome. The gene was shown to be expressed in various tissues and organs, including brain, heart, liver, and muscle. The expression level of LINC02778 was also shown to be regulated by various factors, including DNA methylation and RNA-binding protein (RBP) interactions.

Function and Potential Therapeutic Applications

LINC02778 has been shown to play a role in various cellular processes, including cell adhesion, migration, and tissue repair. It has been shown to be involved in the regulation of cell-cell adhesion, as well as the maintenance of tissue homeostasis during mechanical stress . In addition, LINC02778 has been shown to be involved in the regulation of cell migration and the establishment of tissue repair following injury or disease.

Given its function in various cellular processes, LINC02778 has potential as a drug target for the development of new therapeutic approaches. For example, LINC02778 could be targeted using small molecules or antibodies that specifically interact with its unique structure and function. Additionally, LINC02778 could also be used as a biomarker for the diagnosis and monitoring of various diseases, such as cancer, neurodegenerative diseases, and autoimmune diseases.

Conclusion

LINC02778 is a long intergenic non-protein coding RNA that has been identified in various organisms, including humans. Its unique structure and function have led to its potential as a drug target and biomarker. Further studies are needed to fully understand its role in various cellular processes and its potential as a therapeutic approach.

Protein Name: Long Intergenic Non-protein Coding RNA 2778

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•   expression level;
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