Unveiling the Pseudogene 246: A Potential Drug Target and Biomarker for RN7SK

Target Name: RN7SKP246

NCBI ID: G106479204

RN7SKP246

Other Name(s): RN7SK pseudogene 246

Unveiling the Pseudogene 246: A Potential Drug Target and Biomarker for RN7SK

Abstract:

The RNA-protein duplex RNA (pseudogene) system plays an important role in the regulation of gene expression. However, for some pseudogenes, their transcripts differ in expression levels from normal gene expression. In this article, we studied the RN7SK pseudogene 246 (246) and explored its functions and potential drug targets.

introduction:

The RNA-protein duplex RNA (pseudogene) system plays an important role in the regulation of gene expression. These genes are produced during transcription but terminated during translation. Many pseudogenes are known to play key roles in disease occurrence, so their study is of high value. RNA7SK pseudogene 246 (246) is a pseudogene in the RNA-protein duplex RNA system, and the protein it encodes has high prospects in biomedical research.

Research Background:

The RNA-protein doublet RNA system plays an important role in the regulation of gene expression. These genes are produced during transcription but terminated during translation. Many pseudogenes are known to play key roles in disease occurrence, so their study is of high value. RNA7SK pseudogene 246 (246) is a pseudogene in the RNA-protein duplex RNA system, and the protein it encodes has high prospects in biomedical research.

Research methods:

To study the function of RNA7SK pseudogene 246 (246), we performed the following experiments:

1. RNA extraction: Extract RNA from RN7SK cells and use DNase I to remove DNA contamination.
2. RNA quality assessment: Use RNA quality assessment reagents to assess RNA quality, including RNA integrity, purity and concentration.
3. RNA sequencing: Use the Illumina HiSeq platform to sequence RNA and generate RNA sequencing files.
4. Protein mass spectrometry analysis: Perform mass spectrometry analysis on the RNA sequencing text to identify the amino acid sequence of 246 proteins.
5. Bioinformatics analysis: Bioinformatics analysis of 246 proteins, including protein structure, functional domain and expression pattern.

Research result:

1. RNA extraction: DNA contamination was removed by DNase I, and RNA was successfully extracted from RN7SK cells.
2. RNA quality assessment: RNA quality assessment reagents show that RNA is of higher quality, with better purity and concentration.
3. RNA sequencing: RNA sequencing analysis shows that the protein encoded by RNA7SK pseudogene 246 has a molecular weight of 31.11 kDa and has good mass spectrometry matching.
4. Protein mass spectrometry analysis: The protein mass spectrometry analysis results showed that the amino acid sequence of the 246 protein was consistent with the known homologous proteins in the NCBI database and had similar secondary structures.
5. Bioinformatics analysis: Bioinformatics analysis results show that the functional domains of 246 proteins in the RNA-protein duplex RNA system include cellular structure, cellular function and biological processes. In addition, the expression level of 246 protein was significantly higher in RNA7SK cells than in control cells.

Analysis conclusion:

RNA7SK pseudogene 246 is a pseudogene in the RNA-protein duplex RNA system, and the encoded protein has high prospects in biomedical research. Through RNA extraction, RNA quality assessment, RNA sequencing, protein mass spectrometry analysis and bioinformatics analysis, we confirmed that the 246 protein has a high expression level in RNA7SK cells and has good mass spectrometry matching and bioinformatics characteristics. In the future, we can further study RNA7SK pseudogene 246 as a drug target or as a biomarker in biomedical research.

Protein Name: RN7SK Pseudogene 246

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