CMTM4: A Protein in The Immune System (G146223)

Target Name: CMTM4

NCBI ID: G146223

CMTM4

Other Name(s): Chemokine-like factor superfamily member 4 | CMTM4 variant 1 | CKLF like MARVEL transmembrane domain containing 4 | chemokine-like factor super family 4 | CKLFSF4 | CKLF like MARVEL transmembrane domain containing 4, transcript variant 1 | Chemokine-like factor super family 4 | CKLF4_HUMAN | CKLF-like MARVEL transmembrane domain-containing protein 4 (isoform 1) | CKLF-like MARVEL transmembrane domain-containing protein 4 | chemokine-like factor superfamily member 4

CMTM4: A Protein in The Immune System

CMTM4, also known as chemokine-like factor superfamily member 4, is a protein that plays a crucial role in the immune system. It is a member of the chemokine-like factor (CLF) family, which is a group of proteins that are involved in the regulation of cell signaling processes. CLF proteins are known for their ability to interact with specific cytokines, such as chemokines, and to regulate the production of these cytokines.

CMTM4 is a transmembrane protein that is expressed in a variety of tissues throughout the body. It is primarily localized to the cytoplasm of cells, where it interacts with other cellular components. CMTM4 is involved in the regulation of several cellular processes, including cell signaling, cell adhesion, and cell migration.

One of the key functions of CMTM4 is its role in the regulation of cytokine signaling. It is known to interact with several different cytokines, including TGF-β1, IL-6, and PDGF. These interactions are critical for the regulation of cellular processes such as cell proliferation, differentiation, and survival.

In addition to its role in cytokine signaling, CMTM4 is also involved in the regulation of cell adhesion. It is a member of the cadherin family of transmembrane proteins, which are involved in the regulation of cell-cell adhesion. CMTM4 is known to interact with several different adhesion molecules, including cadherin and E-cadherin. These interactions are critical for the regulation of cell behavior, such as cell migration and tissue organization.

CMTM4 is also involved in the regulation of cell migration. It is a member of the vimentin family of cytoskeletal proteins, which are involved in the regulation of cell structure and movement. CMTM4 is known to interact with several different cytoskeletal proteins, including microtubules and actin. These interactions are critical for the regulation of cell movement and the formation of tissues.

In conclusion, CMTM4 is a protein that plays a crucial role in the immune system. It is involved in the regulation of several cellular processes, including cytokine signaling, cell adhesion, and cell migration. As a result, CMTM4 may be a potential drug target or biomarker for a variety of diseases. Further research is needed to fully understand the functions of CMTM4 and its potential therapeutic uses.

Protein Name: CKLF Like MARVEL Transmembrane Domain Containing 4

Functions: Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation

The "CMTM4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CMTM4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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