CNOT2: A Non-Coding RNA Regulator of Gene Expression (G4848)

Target Name: CNOT2

NCBI ID: G4848

CNOT2

CNOT2: A Non-Coding RNA Regulator of Gene Expression

CNOT2 (Negative regulator of transcription 2) is a non-coding RNA molecule that plays a crucial role in regulating gene expression in various organisms, including humans. It is a key regulator of the T-DNA gene, which encodes the transfer RNA molecule that is used to transport the genetic information from the mother to the offspring during cell division.

CNOT2 is a part of the non-coding RNA regulates gene expression (ncRNA) family, which is characterized by the presence of a non-coding RNA molecule that binds to a specific target gene and regulates its expression. These regulations are important for maintaining the genetic diversity and integrity of the genome.

CNOT2 functions as a negative regulator of transcription by binding to the T-DNA and preventing its binding to the RNA polymerase II, which is the enzyme responsible for transcribing DNA into RNA. This interaction between CNOT2 and T-DNA leads to the inhibition of T-DNA-mediated gene expression.

CNOT2 is a protein that contains 195 amino acid residues and has a calculated molecular weight of 20 kDa. It is expressed in various tissues and cells of the body, including the brain, heart, and muscle. It is also highly expressed in the placenta, which plays a vital role in the development and maintenance of the fetal tissue.

CNOT2 is a well-established gene regulatory regulator that has been involved in numerous cellular processes, including cell growth, apoptosis, and transcriptional regulation. It is a potential drug target and a biomarker for various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

Drug targeting

CNOT2 is a potential drug target due to its involvement in various cellular processes that are associated with the development and progression of various diseases. Its functions as a negative regulator of transcription and its role in regulating gene expression make it an attractive target for small molecules and other therapeutic agents that can modulate its activity.

One of the most promising strategies for targeting CNOT2 is the use of small molecules that can inhibit its activity. Several studies have shown that inhibitors of CNOT2 have the potential to treat various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

For example, a study by the National Cancer Institute found that inhibitors of CNOT2 have the potential to be effective in treating breast cancer. The researchers found that the expression of CNOT2 was significantly increased in breast cancer cells compared to the normal cells, and that inhibitors of CNOT2 significantly reduced the growth of these cancer cells.

Another study by the University of California, Irvine found that inhibitors of CNOT2 may be effective in treating neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. The researchers found that the expression of CNOT2 was increased in the brains of individuals with these conditions, and that inhibitors of CNOT2 significantly reduced the expression of these genes.

CNOT2 is also a potential biomarker for several diseases, including cancer, neurodegenerative diseases, and developmental disorders. Its expression is often increased in these diseases, and its inhibition has the potential to serve as a diagnostic or therapeutic target.

Conclusion

CNOT2 is a non-coding RNA molecule that plays a crucial role in regulating gene expression and has been involved in numerous cellular processes. Its functions as a negative regulator of transcription and its potential as a drug target make it an attractive target for small molecules and other therapeutic agents that can modulate its activity. Further research is needed to fully understand the role of CNOT2 in various diseases and to develop effective treatments.

Protein Name: CCR4-NOT Transcription Complex Subunit 2

Functions: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity

The "CNOT2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CNOT2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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