LIMCH1: A Potential Drug Target for Neurodegenerative Diseases

Target Name: LIMCH1

NCBI ID: G22998

LIMCH1

LIMCH1: A Potential Drug Target for Neurodegenerative Diseases

LIMCH1 (LIM Chicklet gene 1) is a gene that has been identified as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. The LIMCH1 gene is located on chromosome 18 and encodes a protein known as LIM-CH1, which plays a role in the regulation of cell adhesion and signaling pathways.

LIMCH1 is a single-spaced gene that contains 20 exons. It is located on chromosome 18, which is the same chromosome where the insulin gene is located. The gene has a length of 1,922 base pairs and an estimated G-C content of 61%.

The LIMCH1 gene is a member of the LIM family, which is characterized by the presence of a single nucleotide deletion at position -202. This deletion results in the loss of the last exon, which is a stop codon that usually results in the fusion of the gene and the adjacent gene. This loss of an exon can result in a truncation of the gene that affects its function.

The LIMCH1 gene is expressed in many different tissues and cells of the body, including the brain, heart, liver, and gastrointestinal tract. It is also expressed in various cell types, including epithelial cells, endothelial cells, and immune cells. The gene is highly conserved, with only a small number of amino acid differences between the gene and its splice variants.

The LIMCH1 gene has been associated with a number of diseases and conditions, including cancer, neurodegenerative diseases, and autoimmune disorders. One of the most significant associations is with the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. These conditions are characterized by the progressive loss of brain cells and the development of neurofibrillary tangles and neuroglial cells.

LIMCH1 has also been associated with the development of certain cancers, including breast, ovarian, and colorectal cancers. The gene has been shown to be expressed in various types of cancer cells and has been used as a potential biomarker for cancer diagnosis and prognosis.

In addition to its association with cancer, LIMCH1 has also been linked to a number of other conditions and diseases. It has been shown to be involved in the regulation of cell adhesion and signaling pathways, which are important for the development and maintenance of tissues and organs. As a result, LIMCH1 has been potential targets for drugs that can modulate these pathways.

One of the most promising potential drug targets for LIMCH1 is the inhibition of the LIM-CH1 protein. This can be achieved through a variety of methods, including the use of small molecules, antibodies, or genetic modifiers. The use of small molecules has been shown to be effective in modulating LIM-CH1 expression and activity, and may be a useful approach for the treatment of neurodegenerative diseases.

Another potential approach to targeting LIMCH1 is the use of antibodies that recognize and label the protein. This can be a useful approach for the detection and quantification of LIM-CH1 expression in various tissues and cells. Antibodies can also be used to interact with LIM-CH1 and may be useful for the inhibition of its activity.

In addition to the use of antibodies and small molecules, genetic modifiers may also be used to modify LIMCH1 expression. There is evidence to suggest that genetic modifiers, such as RNA interference and CRISPR/Cas9, can be used to alter the expression of LIMCH1 and may be a useful approach for the treatment of certain diseases.

Overall, the LIMCH1 gene is a promising target for the development of new drugs and therapies. Its association with the development of neurodegenerative diseases and its potential as a drug target make it an attractive target for research in this field. Further research is needed to fully understand the functions of LIMCH1 and its potential as a drug target.

Protein Name: LIM And Calponin Homology Domains 1

Functions: Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration

The "LIMCH1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LIMCH1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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