LIMK2: A Protein Involved in Cell Signaling, Division and Survival

Target Name: LIMK2

NCBI ID: G3985

LIMK2

LIMK2: A Protein Involved in Cell Signaling, Division and Survival

LIMK2 (LIM domain kinase 2) is a protein that is expressed in various cell types, including neurons, muscle cells, and cancer cells. It is a member of the LIMK family of proteins, which are known for their role in intracellular signaling. The LIMK2 protein has been shown to play a role in a variety of cellular processes, including cell signaling, cell division, and the regulation of cell survival.

One of the key functions of LIMK2 is its role in the regulation of cell signaling. LIMK2 has been shown to play a negative role in the regulation of cell proliferation, by inhibiting the activity of the protein p53. This means that when LIMK2 is activated, it can cause p53 to become less active, which can lead to the growth and survival of cells that should normally be stopped.

Another function of LIMK2 is its role in the regulation of cell division. LIMK2 has been shown to play a positive role in the regulation of cell division, by encouraging the activity of the protein p21. This means that when LIMK2 is activated, it can cause p21 to become more active, which can lead to the formation of cell plates and the completion of cell division.

In addition to its role in cell signaling, LIMK2 has also been shown to play a number of other roles in cellular processes. For example, it has been shown to play a role in the regulation of cell migration, by encouraging the activity of the protein vimentin. This means that when LIMK2 is activated, it can cause vimentin to become more active, which can lead to the movement of cells along the cell membrane and the formation of new cell-cell junctions.

Another function of LIMK2 is its role in the regulation of cell survival. LIMK2 has been shown to play a negative role in the regulation of cell survival, by inhibiting the activity of the protein BCL-2. This means that when LIMK2 is activated, it can cause BCL-2 to become less active, which can lead to the survival of cells that should normally be dead.

In conclusion, LIMK2 is a protein that plays a number of important roles in cellular processes, including cell signaling, cell division, and cell survival. As a result, it is a potential drug target for researchers who are interested in the regulation of these processes. Further research is needed to fully understand the role of LIMK2 in cellular processes, and to determine the best way to target it in order to improve human health.

Protein Name: LIM Domain Kinase 2

Functions: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042). Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11018042). Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP (PubMed:22328514). Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro (PubMed:8537403). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865)

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•   general information;
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•   expression level;
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