BHMT2: Key Enzyme for S-Methylation of Homocysteine (G23743)

Target Name: BHMT2

NCBI ID: G23743

BHMT2

Other Name(s): S-methylmethionine--homocysteine S-methyltransferase BHMT2 | BHMT2_HUMAN | S-methylmethionine--homocysteine S-methyltransferase BHMT2 (isoform 2) | SMM-hcy methyltransferase | S-methylmethionine--homocysteine S-methyltransferase BHMT2 (isoform 1) | BHMT2 variant 1 | FLJ20001 | Betaine-homocysteine methyltransferase 2 | betaine--homocysteine S-methyltransferase 2 | Betaine--homocysteine S-methyltransferase 2 | betaine-homocysteine methyltransferase 2 | Betaine--homocysteine S-methyltransferase 2, transcript variant 1 | Betaine--homocysteine S-methyltransferase 2, transcript variant 2 | BHMT2 variant 2

BHMT2: Key Enzyme for S-Methylation of Homocysteine

BHMT2 (S-methylmethionine--homocysteine S-methyltransferase BHMT2) is a gene that encodes a protein known as BHMT2. The protein produced by this gene is involved in the metabolism of a specific molecule, known as homocysteine. Homocysteine is a sulfur compound that is found in many proteins, as well as in the DNA and RNA of living organisms. It is a potent antioxidant that can interact with many different molecules, including proteins and nucleic acids.

One of the unique features of BHMT2 is its ability to transfer a sulfur atom from the homocysteine molecule to a methyl group on the carbon atom of the adjacent carbon atom. This transfer of a sulfur atom to a methyl group is a critical step in the metabolism of homocysteine, and is a process that is known as S-methylation.

BHMT2 is a key enzyme involved in the S-methylation of homocysteine. It is a protein that is expressed in many different tissues and organs, including the brain, heart, and kidneys. It is also expressed in various cell types, including muscle, nerve, and liver cells.

One of the potential applications of BHMT2 as a drug target is its ability to modulate the levels of homocysteine in the body. High levels of homocysteine have been linked to a number of different health problems, including cardiovascular disease, neurodegenerative diseases, and certain cancers. By reducing the levels of homocysteine, it may be possible to reduce the risk of these diseases.

In addition to its potential as a drug target, BHMT2 may also be used as a biomarker for certain diseases. For example, high levels of homocysteine have been linked to the development of certain neurological conditions, such as Alzheimer's disease and Parkinson's disease. By measuring the levels of homocysteine in the brain, it may be possible to diagnose these conditions based on the levels of this compound.

Another potential application of BHMT2 is its role in the regulation of cellular processes. BHMT2 is involved in the metabolism of various cellular molecules, including DNA, RNA, and proteins. It is also involved in the regulation of cellular processes such as cell growth, apoptosis (programmed cell death), and inflammation.

In conclusion, BHMT2 is a protein that is involved in the S-methylation of homocysteine. It is a key enzyme in the metabolism of homocysteine and has the potential as a drug target and biomarker. Further research is needed to fully understand the role of BHMT2 in the regulation of cellular processes and the development of various diseases.

Protein Name: Betaine--homocysteine S-methyltransferase 2

Functions: Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor

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