LSM4: A Potential Drug Target and Biomarker (G25804)

Target Name: LSM4

NCBI ID: G25804

LSM4

LSM4: A Potential Drug Target and Biomarker

Introduction

LSM4 (U6 snRNA-associated Sm-like protein LSm4, isoform 1) is a protein that has been identified as a potential drug target and biomarker. It is a key regulator of gene expression and has been shown to play a role in a variety of cellular processes, including cell growth, apoptosis, and transcriptional regulation. In this article, we will explore the biology of LSM4 and its potential as a drug target and biomarker.

biological background

LSM4 is a small protein coexpressed on U6 snRNA, its isoform 1 isoform. LSM4 plays a key role in the transcription process, regulating gene expression. Studies have shown that LSM4 plays an important role in cell growth, apoptosis and transcriptional regulation. In this article, we explore the biology of LSM4 and examine its potential as a drug target and biomarker.

LSM4 features

LSM4 is a transcription factor that mainly plays a role in the RNA splicing process. Studies have shown that LSM4 can bind to U6 snRNA and affect its stability through phosphorylation modification. The phosphorylation modification of LSM4 is reversible, meaning that it can be repeatedly phosphorylated at different concentrations, giving it a stable expression level in cells.

Protein structure of LSM4

The protein structure of LSM4 has been determined. It consists of 159 amino acids with a single polypeptide chain. The N-terminus of LSM4 is formed by an 伪-helix, a secondary structure that gives LSM4 a compact shape. The C-terminus of LSM4 is composed of an incomplete 伪-helix and a 尾-sheet. These structures give LSM4 a better three-dimensional structure and the ability to interact with other proteins.

Functional domains of LSM4

The functional domain of LSM4 includes an N-terminal 伪-helix, a central 尾-sheet, and a C-terminal domain. The N-terminal 伪-helix is 鈥嬧?媋 critical region for LSM4 to bind to its paired U6 snRNA. The central 尾-sheet is the secondary functional domain of LSM4 and is responsible for stabilizing the protein structure of LSM4. The C-terminal domain includes an 伪-helix, a 尾-sheet, and a phosphorylation-modified region. The phosphorylation modification region is the key region for LSM4 phosphorylation modification, which can affect its stability and function.

LSM4 interaction

LSM4 interacts with other proteins in cells, including the proteins that make up LSM4 and other proteins. Studies have shown that LSM4 can interact with a variety of proteins, including histones, HIS110, AP1 and HIF1伪. These interactions contribute to LSM4's stability and function.

Pharmacological significance of LSM4

LSM4 is a protein of potential pharmacological significance. Studies have shown that LSM4 can inhibit cell proliferation and induce apoptosis. In addition, LSM4 can also regulate the cell cycle and promote cell progression into the cell cycle. These pharmacological effects make LSM4 a potential drug target.

Biological significance of LSM4

LSM4 is of great significance in biology. First, LSM4 is a transcription factor that regulates gene expression and plays an important role in cell growth, apoptosis, and transcriptional regulation. Secondly, LSM4 can be used as a drug target and has potential pharmacological significance. In addition, LSM4 can also be used as a biomarker to detect diseases and drug efficacy.

in conclusion

LSM4 is a small protein co-expressed on U6 snRNA and plays a key role in the transcription process. It is a potential drug target with broad biological significance. In the future, research will continue to delve into the application of LSM4 in drug discovery and biomarker diagnosis to achieve better therapeutic effects.

Protein Name: LSM4 Homolog, U6 Small Nuclear RNA And MRNA Degradation Associated

Functions: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320)

The "LSM4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LSM4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets