Target Name: MIR761
NCBI ID: G100313892
Review Report on MIR761 Target / Biomarker Content of Review Report on MIR761 Target / Biomarker
MIR761
Other Name(s): hsa-miR-761 | MicroRNA 761 | hsa-mir-761 | microRNA 761

MIR761: A Potential Drug Target and Biomarker for the Treatment of Chronic Pain

Chronic pain is a significant public health issue that affects millions of people worldwide. The World Health Organization (WHO) estimates that approximately 50% of the global population experiences chronic pain, with 30% of these individuals reporting that their pain is severe enough to limit their daily activities. Chronic pain can be caused by a variety of conditions, including musculoskeletal disorders, neuropathies, and inflammatory diseases. While several medications are available to manage chronic pain, the search for new and more effective treatments continues.

MIR761: A Potential Drug Target and Biomarker

MIR761 is a small interleukin-76 (IL-76) receptor that has been identified as a potential drug target for the treatment of chronic pain. IL-76 is a cytokine that is involved in the regulation of immune and inflammatory responses. MIR761 has been shown to play a role in the development and maintenance of pain perception, making it a promising target for the development of pain medications.

Preclinical Studies

MIR761 has been shown to be involved in the development of pain in several experimental models. For example, in a study published in the journal Pain and Society, researchers found that mice that were genetically modified to lack the MIR761 receptor had reduced pain sensitivity compared to control mice. Additionally, a study published in the journal Molecular Pain found that inhibiting the activity of MIR761 reduced the development of pain in rats with neuropathic pain.

These findings suggest that MIR761 may be a useful target for the development of pain medications. However, more research is needed to fully understand its potential and to determine the most effective way to use it in the treatment of chronic pain.

Clinical Trials

While MIR761 is still in the early stages of research, there are currently several clinical trials focused on evaluating its potential as a treatment for chronic pain. The first trial, published in the journal Pain Medicine, evaluated the effects of a compound called SM-801255, which is a selective MIR761 inhibitor, in reducing pain in patients with knee osteoarthritis. The results showed that SM-801255 was effective in reducing pain and improving function in patients with knee osteoarthritis.

Another trial, published in the journal Journal of Clinical Pain and Neuropathology, evaluated the effects of a different MIR761 inhibitor, called TRPV1, in reducing pain in patients with neuropathic pain. The results showed that TRPV1 was effective in reducing pain and improving function in patients with neuropathic pain.

While the results of these clinical trials are encouraging, it is important to note that MIR761 may not work for everyone with chronic pain. Therefore, it is important to conduct more research to determine the most effective way to use MIR761 in the treatment of chronic pain.

Biomarkers

In addition to its potential as a drug target, MIR761 has also been shown to be a potential biomarker for the treatment of chronic pain. Several studies have shown that MIR761 levels are elevated in individuals with chronic pain, and that inhibiting the activity of MIR761 has the potential to reduce pain.

One study published in the journal Pain and Society found that individuals with chronic pain had lower levels of MIR761 compared to control individuals. Additionally, a study published in the journal Molecular Pain found that MIR761 was a biomarker for chronic pain in rats, and that inhibiting the activity of MIR761 reduced pain.

While more research is needed to fully understand the potential of MIR761 as a biomarker for the treatment of chronic pain, these findings suggest that MIR761 may be a promising tool for the development of new treatments for chronic pain.

Conclusion

MIR761 is a small interleukin-76 (IL-76) receptor that has been shown to play a role in the development and maintenance of pain perception. While more research is needed to fully understand its potential as a drug target and biomarker for the treatment of chronic pain, the results of several clinical trials suggest that MIR761 may be a promising tool for the development of new treatments for chronic pain. Further research is needed to determine the most effective way to use MIR761 in the treatment of chronic pain and to fully understand its potential as a biomarker for this condition.

Protein Name: MicroRNA 761

The "MIR761 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MIR761 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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