RPAP1: A Key Player in Gene Expression and Cellular Processes

Target Name: RPAP1

NCBI ID: G26015

RPAP1

Other Name(s): RNA polymerase II associated protein 1 | RNA polymerase II-associated protein 1 | KIAA1403 | RPAP1_HUMAN

RPAP1: A Key Player in Gene Expression and Cellular Processes

RNA polymerase II (RPN) is a key enzyme in the process of gene expression, responsible for creating the double-stranded RNA molecule that serves as the blueprint for protein synthesis. RPN is a protein that is highly conserved across various species, and it plays a crucial role in the development, growth, and progression of many diseases. One of the proteins that is highly associated with RPN is RPAP1 (RNA polymerase II associated protein 1), a protein that is expressed in high levels in many diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

RPAP1 is a protein that is composed of 158 amino acids and has a calculated molecular weight of 17 kDa. It is located at the N-terminus of the large subunit of RPN and is highly conserved in its sequence, with only four amino acids being different between the human and mouse RPAP1 proteins. RPAP1 is a glycoprotein and its cytoplasmic localization suggests that it may be involved in various cellular processes, including cell signaling, protein synthesis, and stress response.

One of the key functions of RPAP1 is its role in the regulation of RPN activity. RPAP1 has been shown to interact with RPN and to regulate its activity in various cellular processes. For example, studies have shown that RPAP1 can inhibit the activity of RPN and to prevent the initiation of protein synthesis by RPN. This suggests that RPAP1 plays a negative role in the regulation of gene expression and that it may be a potential drug target or biomarker.

In addition to its role in regulating RPN activity, RPAP1 has also been shown to be involved in the regulation of cellular processes such as cell adhesion, migration, and invasion. Studies have shown that RPAP1 is highly expressed in various tissues and that it is involved in the regulation of cellular processes such as cell-cell adhesion, migration, and invasion. This suggests that RPAP1 may be a potential therapeutic target or biomarker for various diseases, including cancer and neurodegenerative diseases.

RPAP1 has also been shown to be involved in the regulation of protein synthesis and to play a role in the stress response. Studies have shown that RPAP1 can interact with various protein synthesis factors and that it can regulate the activity of these factors. This suggests that RPAP1 may be involved in the regulation of protein synthesis and that it may be a potential drug target or biomarker for various diseases.

In conclusion, RPAP1 is a protein that is highly conserved across various species and that is involved in various cellular processes, including cell signaling, protein synthesis, and stress response. Studies have shown that RPAP1 can inhibit the activity of RPN and that it can be involved in the regulation of cellular processes such as cell-cell adhesion, migration, and invasion. In addition, RPAP1 has also been shown to be involved in the regulation of protein synthesis and that it may be a potential drug target or biomarker for various diseases. Further research is needed to fully understand the role of RPAP1 in cellular processes and its potential as a drug target or biomarker.

Protein Name: RNA Polymerase II Associated Protein 1

Functions: Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3

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•   general information;
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•   expression level;
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