RPL15P4: A Promising Drug Target / Biomarker (G100129921)

Target Name: RPL15P4

NCBI ID: G100129921

RPL15P4

Other Name(s): RPL15_4_680 | Em:AC006046.2 | ribosomal protein L15 pseudogene 4 | Ribosomal protein L15 pseudogene 4

RPL15P4: A Promising Drug Target / Biomarker

The protein RPL15P4 is a key regulator of the Replication Protein Complex (RPC), which is responsible for copying DNA in the human genome. RPL15P4 has been identified as a potential drug target and has been the focus of research in the field of gene therapy. In this article, we will explore the biology of RPL15P4 and its potential as a drug target.

Background

RPL15P4 is a 21 kDa protein that is expressed in a variety of tissues, including muscle, heart, brain, and placenta. It is a key component of the RPC, which is a complex of proteins that plays a critical role in the replication of DNA in the human genome. The RPC is composed of several subunits, including RPL15P4, which is responsible for the recruitment of DNA to the replication fork.

Function

RPL15P4 is a critical regulator of DNA replication. It functions as a binding protein for the DNA template, allowing it to recruit DNA to the replication fork. RPL15P4 is also involved in the regulation of the timing of DNA replication, as it is able to delay the start of replication until the DNA template is fully loaded onto the replication fork. This allows the DNA to be accurately duplicated, which is essential for the development and maintenance of a healthy genome.

Drug Target Potential

RPL15P4 has been identified as a potential drug target due to its involvement in the regulation of DNA replication. Its function as a binding protein for DNA templates makes it an attractive target for small molecules that can modulate DNA replication. In addition, RPL15P4 is also involved in the regulation of the timing of DNA replication, which makes it an attractive target for drugs that can alter the timing of replication.

Molecular Mechanisms

The molecular mechanisms underlying the regulation of RPL15P4 by drugs are not well understood. However, research has shown that RPL15P4 is able to interact with small molecules, such as inhibitors of DNA replication, and that these interactions can modulate its function.

One of the key mechanisms by which RPL15P4 is regulated by small molecules is through its interaction with the DNA template. The DNA template is loaded onto the replication fork by the complex of the protein Rec2, which is a cofactor of RPL15P4, and the DNA-binding protein P1. RPL15P4 is able to interact with the DNA template and prevent Rec2 from binding to it. This interaction between RPL15P4 and the DNA template allows RPL15P4 to regulate the timing of DNA replication and function as a binding protein for DNA templates.

Another mechanism by which RPL15P4 is regulated by small molecules is through its interaction with the regulatory protein Prm1. Prm1 is a protein that is involved in the regulation of DNA replication, and it is able to interact with RPL15P4 to modulate its function. This interaction between Prm1 and RPL15P4 allows Prm1 to regulate the timing of DNA replication and function as a binding protein for DNA templates.

Preclinical Studies

Preclinical studies have shown that RPL15P4 is a potential drug target for small molecules. Studies have shown that inhibitors of DNA replication, such as the small molecule DMF, can modulate the function of RPL15P4. In addition, studies have shown that RPL15P4 is able to interact with small molecules, such as the DNA-binding protein p120, and that these interactions can modulate its function.

Despite these promising results, more research is needed to fully understand the mechanisms of

Protein Name: Ribosomal Protein L15 Pseudogene 4

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