CMKLR2: A Potential Drug Target and Biomarker for Many Diseases

Target Name: CMKLR2

NCBI ID: G2825

CMKLR2

CMKLR2: A Potential Drug Target and Biomarker for Many Diseases

Chemerin chemokine-like receptor 2 (CMKLR2) is a protein that is expressed in various tissues throughout the body, including the skin, hair, and nails. It is a member of the chemokine receptor family, which includes proteins that are involved in the regulation of immune and inflammatory responses.

CMKLR2 is involved in the regulation of skin inflammation, which is a critical function for many organisms. When the body is exposed to an infection or injury, the immune system sends a response to protect the body from the invading microorganisms. This response involves the production of inflammatory cytokines, which are proteins that help to recruit and activate immune cells.

CMKLR2 is involved in the regulation of the production of these cytokines. It is known to be involved in the signaling pathway that regulates the production of cytokines by immune cells. This pathway involves the interaction between CMKLR2 and the cytokine receptor PD-1.

PD-1 is a protein that is expressed in many different tissues throughout the body, including the immune system. It is involved in the regulation of immune responses, and is often targeted by drugs that are used to treat cancer.

CMKLR2 is a potential drug target for PD-1-based therapies because it is involved in the regulation of the production of cytokines, which are often targeted by these therapies. By inhibiting the activity of PD-1, researchers may be able to reduce the production of cytokines, which could potentially reduce the inflammation that is associated with many different diseases.

In addition to its potential role as a drug target, CMKLR2 is also a potential biomarker for some diseases. The production of cytokines by immune cells is often a reliable indicator of inflammation in the body. This means that if the production of these cytokines is reduced, it may be a sign of reduced inflammation.

For this reason, CMKLR2 is being studied as a potential biomarker for a number of different diseases, including cancer, autoimmune disorders, and inflammatory skin conditions. Because it is involved in the regulation of the production of cytokines, CMKLR2 may be a useful target for drugs that are used to treat these conditions.

Overall, CMKLR2 is a protein that is involved in the regulation of many different processes in the body. Its potential as a drug target and biomarker make it an attractive target for researchers who are working to develop new treatments for a variety of diseases.

Protein Name: Chemerin Chemokine-like Receptor 2

Functions: Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis (PubMed:18165312, PubMed:27716822). Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too (PubMed:27716822). Acts also as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity)

The "CMKLR2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CMKLR2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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