LINC01148: A Long Intergenic Non-Protein Coding RNA (G283585)

Target Name: LINC01148

NCBI ID: G283585

LINC01148

Other Name(s): long intergenic non-protein coding RNA 1148 | Long intergenic non-protein coding RNA 1148

LINC01148: A Long Intergenic Non-Protein Coding RNA

Non-Protein-Coding RNAs (NP-C RNAs) have emerged as a promising source of new biomarkers and drug targets in recent years. These RNAs are not protein-coding, meaning they do not contain the amino acid sequence typically associated with protein production . Instead, they are derived from genomic regions that are not typically expressed in proteins. LINC01148 is a well-known example of an NP-C RNA that has gained interest as a potential drug target or biomarker.

LINC01148 is a long intergenic non-protein coding RNA (lncRNA) that is located on chromosome 16 at position 255. It is approximately 200 nucleotides in length and has a 5'-end that is upstream coding element (promoter) and 3'- end, and 6'-end is the open reading frame (ORF) region. LINC01148 plays an important role in biological processes such as gene expression regulation, cell cycle, apoptosis, immune response and metabolism.

LINC01148 carries multiple functional regions and variants, which can affect its expression levels. The study found that the expression level of LINC01148 is affected by a variety of regulatory elements, including DNA binding elements, RNA binding elements and RNA interference (RNAi) elements. In addition, LINC01148 is also subject to interactions with some proteins, such as miRNA (miRNA-202), which may be involved in regulating the expression of LINC01148.

LINC01148 plays an important role in a variety of diseases, including cancer, neurodegenerative diseases, immune deficiencies and metabolic disorders. For example, studies have shown that LINC01148 is up-regulated in a variety of cancers, such as lung cancer, liver cancer, breast cancer, etc. In addition, LINC01148 has been linked to neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

LINC01148 also proved to be a potential drug target. For example, the researchers found that LINC01148 can be inhibited by a drug called Xinlitai, which is a selective RNA interference (RNAi) inhibitor. Through RNAi technology, the expression level of LINC01148 was reduced, thereby inhibiting the anti-tumor effect of the drug. In addition, some studies have also shown that LINC01148 can be used as a target for certain immunotherapy, such as peptide vaccines and DNA vaccines.

LINC01148, as a new type of non-protein-coding RNA, has broad biological significance. It plays an important role in biological processes and exhibits important biological functions in many diseases. In addition, LINC01148 is also a potential drug target and can be used as an important tool for studying gene function and developing new drugs. With the deepening of research, LINC01148 will play a more important role in biological and drug research.

Protein Name: Long Intergenic Non-protein Coding RNA 1148

The "LINC01148 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LINC01148 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets