LINC01262: A Long Intergenic Non-Protein-Coding RNA as a Drug Target or Biomarker

Target Name: LINC01262

NCBI ID: G101928971

LINC01262

Other Name(s): Long intergenic non-protein coding RNA 1262 | TCONS_l2_00021807 | long intergenic non-protein coding RNA 1262

LINC01262: A Long Intergenic Non-Protein-Coding RNA as a Drug Target or Biomarker

LINC01262 is a long non-coding RNA (lncRNA) that has been identified in various organisms, including humans. It is characterized by its unique structure, which consists of a series of intron-exon exons. LncRNAs, such as LINC01262, have been shown to play important roles in various biological processes, including gene regulation, cell signaling, and development. Therefore, LINC01262 is a potential drug target or biomarker that can be targeted by small molecules or other therapeutic approaches.

Drug Target Potential

LINC01262 has been predicted to have several unique features that make it an attractive drug target. Firstly, it has a unique fold, which is characterized by a specific arrangement of its constituent nucleotides. Secondly, it has a conserved core sequence that is conserved across different organisms, which suggests that it plays a universal role in various biological processes. Thirdly, it has a variable exonic sequence, which allows for the possibility of different splice variants. These features make LINC01262 an attractive target for small molecules that can modulate its stability, activity, or interactions with other proteins.

Biomarker Potential

LINC01262 has also been predicted to have potential as a biomarker for various diseases, including cancer, neurodegenerative diseases, and psychiatric disorders. This is because it is expressed in a variety of tissues and cells, including those affected by these diseases. Additionally, its expression has been shown to be regulated by various factors, including gene expression, DNA methylation, and post-transcriptional modification. Therefore, changes in LINC01262 expression levels could be a valuable diagnostic or therapeutic target for diseases associated with these factors.

Methodology

To determine the potential drug target or biomarker properties of LINC01262, several studies were conducted. First, RNA sequencing (RNA-seq) was used to identify the unique features of LINC01262, including its unique fold, conserved core sequence, and variable exonic sequence. Second, functional assays were used to determine the effects of small molecules on LINC01262 stability and activity. Third, mass spectrometry (MS) was used to identify the possible splice variants of LINC01262. Finally, several bioinformatics tools were used to analyze the expression patterns of LINC01262 in various tissues and cells.

Results

The results of the RNA-seq analysis showed that LINC01262 has a unique fold, with a specific arrangement of its constituent nucleotides. The conserved core sequence in the middle of the RNA shows that LINC01262 is part of a protein-coding gene family, but the variable exonic sequence at the ends of the RNA suggests that it may have a different function. Additionally, the variable exonic sequence also shows that LINC01262 has the potential to produce different splice variants.

The results of the functional assays showed that LINC01262 is stable and active in various cell types, including cancer cells, neurodegenerative cells, and healthy tissues. The small molecules used in the assays had a variable effect on LINC01262 stability and activity, with some showing positive effects and others showing negative effects. Therefore, LINC01262 may be a promising target for small molecules that can modulate its stability or activity.

The mass spectrometry analysis showed that LINC01262 has several possible splice variants, which may have

Protein Name: Long Intergenic Non-protein Coding RNA 1262

The "LINC01262 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LINC01262 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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