IGFBP1: A Protein Regulating IGF Receptor Signaling (G3484)

Target Name: IGFBP1

NCBI ID: G3484

IGFBP1

IGFBP1: A Protein Regulating IGF Receptor Signaling

Growth hormone independent-binding protein (IGFBP1) is a protein that plays a critical role in the regulation of growth and development. It is a member of the insulin-like growth factor binding protein (IGFBP) family, which is characterized by the presence of a unique N-terminal domain that binds to insulin-like growth factor (IGF) receptors. While IGFBP1 is not a hormone that is directly produced by the body, it plays a significant role in the regulation of IGF signaling.

The IGFBP1 protein is synthesized in the liver and has been shown to be expressed in various tissues, including liver, muscle, and fat. It is also highly conserved, with significant sequence identity across different species, including humans.

IGFBP1 functions as an IGF receptor substrate, meaning that it can bind to the IGF receptor, which is a transmembrane protein that plays a central role in the regulation of cellular growth and differentiation. The IGFBP1 protein is critical for the regulation of cellular growth, as it can either activate or inhibit the activity of the IGF receptor depending on the context.

IGFBP1 has been shown to play a significant role in the regulation of cellular processes that are important for growth and development, including cell proliferation, differentiation, and survival. It has been shown to regulate the activity of several cellular signaling pathways, including the TGF-β pathway, the Wnt pathway, and the Hedgehog pathway.

One of the most significant functions of IGFBP1 is its ability to regulate the activity of the IGF receptor. IGFBP1 has been shown to bind to the IGF receptor with high affinity and can either activate or inhibit its activity depending on the state of the cell. When IGFBP1 is bound to the IGF receptor, it can activate the downstream signaling pathway, which includes the regulation of cell proliferation, differentiation, and survival.

IGFBP1 has also been shown to regulate the activity of several other signaling pathways that are important for growth and development. For example, IGFBP1 has been shown to regulate the activity of the TGF-β pathway, which is involved in the regulation of cell proliferation and differentiation. IGFBP1 has also been shown to regulate the activity of the Wnt pathway, which is involved in the regulation of cell proliferation and the development of tissues.

In addition to its role in regulating the IGF receptor, IGFBP1 has also been shown to play a significant role in the regulation of cellular processes that are important for survival. For example, IGFBP1 has been shown to regulate the activity of several signaling pathways that are involved in the regulation of cell survival, including the apoptosis pathway.

IGFBP1 has also been shown to play a significant role in the regulation of cellular processes that are important for inflammation. For example, IGFBP1 has been shown to regulate the activity of several signaling pathways that are involved in the regulation of inflammation, including the NF-kappa-B pathway.

In conclusion, IGFBP1 is a protein that plays a critical role in the regulation of growth and development. It is a member of the IGFBP family and has been shown to function as an IGF receptor substrate, as well as play a significant role in the regulation of cellular processes that are important for growth, development, and survival. Therefore, IGFBP1 may be a potential drug target or biomarker for the treatment of various diseases.

Protein Name: Insulin Like Growth Factor Binding Protein 1

Functions: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration

The "IGFBP1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about IGFBP1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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